Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying
development and disease, but the considerable phenotypic variation between lines makes it …

Long-read single-cell RNA sequencing (scRNA-seq) enables the quantification of RNA
isoforms in individual cells. However, long-read scRNA-seq using the Oxford Nanopore …

Aims CD47 is overexpressed in multiple tumours and plays an important role in immune
escape and other biological processes of tumours. However, its role in adamantinomatous …

SPG7 is the most common form of autosomal recessive hereditary spastic paraplegia (HSP).
There is a lack of HSP-SPG7 human neuronal models to understand the disease …

Inhibitory neurons originating from the ventral forebrain are associated with several
neurological conditions. Distinct ventral forebrain subpopulations are generated from …

The meninges act as a regulator of brain development by secreting ligands that act on
neural cells to regulate neurogenesis and neuronal migration. Meningeal-derived retinoic …

High-throughput imaging allows in vitro assessment of neuron morphology for screening
populations under developmental, homeostatic, and/or disease conditions. Here, we present …

Although current stem cell therapies exhibit promising potential, the extended process of
employing autologous cells and the necessity for donor–host matching to avert the rejection …

The development of human cell-based platforms for disease modeling, drug discovery, and
regenerative therapy relies on robust and practical methods to derive high yields of relevant …

Disordered cellular development, abnormal neuroanatomical formations, and dysfunction of
neuronal circuitry are among the pathological manifestations of cortical regions in the brain …