The biological applications of DNA nanomaterials: current challenges and future directions

W Ma, Y Zhan, Y Zhang, C Mao, X Xie… - Signal transduction and …, 2021 - nature.com
DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …

mRNA vaccines in disease prevention and treatment

G Zhang, T Tang, Y Chen, X Huang… - Signal transduction and …, 2023 - nature.com
Abstract mRNA vaccines have emerged as highly effective strategies in the prophylaxis and
treatment of diseases, thanks largely although not totally to their extraordinary performance …

[HTML][HTML] Engineering nanoparticle toolkits for mRNA delivery

B Sun, W Wu, EA Narasipura, Y Ma, C Yu… - Advanced Drug Delivery …, 2023 - Elsevier
The concept of using mRNA to produce its own medicine in situ in the body makes it an ideal
drug candidate, holding great potential to revolutionize the way we approach medicine. The …

Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems

S Guan, J Rosenecker - Gene therapy, 2017 - nature.com
Because of its safe and effective protein expression profile, in vitro transcribed messenger
RNA (IVT-mRNA) represents a promising candidate in the development of novel …

Nanomedicines to deliver mRNA: state of the art and future perspectives

I Gómez-Aguado, J Rodríguez-Castejón… - Nanomaterials, 2020 - mdpi.com
The use of messenger RNA (mRNA) in gene therapy is increasing in recent years, due to its
unique features compared to plasmid DNA: Transient expression, no need to enter into the …

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

N Pardi, AJ Secreto, X Shan, F Debonera… - Nature …, 2017 - nature.com
Monoclonal antibodies are one of the fastest growing classes of pharmaceutical products,
however, their potential is limited by the high cost of development and manufacturing. Here …

Functional biomaterials for bone regeneration: a lesson in complex biology

AR Armiento, LP Hatt… - Advanced Functional …, 2020 - Wiley Online Library
Bone is a hard yet dynamic tissue with remarkable healing capacities. Research to date has
greatly advanced the understanding of how bone heals and has led to marked success in …

Nanomedicine-based approaches for mRNA delivery

S Uchida, F Perche, C Pichon… - Molecular …, 2020 - ACS Publications
Messenger RNA (mRNA) has immense potential for developing a wide range of therapies,
including immunotherapy and protein replacement. As mRNA presents no risk of integration …

3D bioprinting of developmentally inspired templates for whole bone organ engineering

AC Daly, GM Cunniffe, BN Sathy, O Jeon… - Advanced …, 2016 - Wiley Online Library
The ability to print defined patterns of cells and extracellular‐matrix components in three
dimensions has enabled the engineering of simple biological tissues; however, bioprinting …

Nanomaterials for mRNA‐based therapeutics: Challenges and opportunities

D Li, Q Liu, M Yang, H Xu, M Zhu… - Bioengineering & …, 2023 - Wiley Online Library
Messenger RNA (mRNA) holds great potential in developing immunotherapy, protein
replacement, and genome editing. In general, mRNA does not have the risk of being …