Bayesian inference is a powerful statistical paradigm that has gained popularity in many
fields of science, but adoption has been somewhat slower in biophysics. Here, I provide an …

Ba2+, a doubly charged analogue of K+, specifically blocks K+ channels by virtue of
electrostatic stabilization in the permeation pathway. Ba2+ block is used here as a tool to …

The ability to measure the properties of proteins at the single-molecule level offers an
unparalleled glimpse into biological systems at the molecular scale. The interpretation of …

Ion channels are characterized by inherently stochastic behavior which can be represented
by continuous-time Markov models (CTMM). Although methods for collecting data from …

Bayesian nonparametric methods have recently transformed emerging areas within data
science. One such promising method, the infinite hidden Markov model (iHMM), generalizes …

The stochastic behavior of single ion channels is most often described as an aggregated
continuous-time Markov process with discrete states. For ligand-gated channels each state …

Single-molecule kinetic experiments allow the reaction trajectories of individual
biomolecules to be directly observed, eliminating the effects of population averaging and …

Type-II ryanodine receptor channels (RYRs) play a fundamental role in intracellular Ca2+
dynamics in heart. The processes of activation, inactivation, and regulation of these …

The liver performs critical physiological functions, including metabolizing and removing
substances, such as toxins and drugs, from the bloodstream. Hepatotoxicity itself is …

Toward the last quarter of the 20th century, the emergence of single-molecule experiments
enabled scientists to track and study individual molecules' dynamic properties in real time …