Fibroblast growth factor 21 (FGF21) is a peptide hormone that is synthesized by several
organs and regulates energy homeostasis. Excitement surrounding this relatively recently …

Exercise is an effective strategy for preventing and treating obesity and its related
cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue …

Since its identification in 2000, the interest of scientists in the hepatokine fibroblast growth
factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very …

Summary Fibroblast growth factor-21 (FGF21) is a circulating hepatokine that beneficially
affects carbohydrate and lipid metabolism. Here, we report that FGF21 is also an inducible …

FGF21 is a novel metabolic regulator involved in the control of glucose homeostasis, insulin
sensitivity, and ketogenesis. The liver has been considered the main site of production and …

BACKGROUND & AIMS: Fibroblast growth factor 21 (FGF21), a hormone primarily secreted
by the liver in response to peroxisome proliferator-activated receptor-α (PPARα) activation …

Summary Fibroblast growth factor 21 (FGF 21), a metabolic hormone predominantly
produced by the liver, is also expressed in adipocytes and the pancreas. It regulates glucose …

The hormone FGF21 regulates carbohydrate and lipid homeostasis as well as body weight,
and increasing FGF21 improves metabolic abnormalities associated with obesity and …

Plasma FGF21 levels and hepatic FGF21 gene expression increase dramatically after birth
in mice. This induction is initiated by suckling, requires lipid intake, is impaired in PPARα …

Sensing and responding to changes in nutrient levels, including those of glucose, lipids, and
amino acids, by the body is necessary for survival. Accordingly, perturbations in nutrient …