Over the past two decades, nuclear magnetic resonance (NMR) has emerged as one of the
three principal analytical techniques used in metabolomics (the other two being gas …

Magnetic resonance (MR) is one of the most versatile and useful physical effects used for
human imaging, chemical analysis, and the elucidation of molecular structures. However, its …

The intensity of NMR signals can be enhanced by several orders of magnitude by using
various techniques for the hyperpolarization of different molecules. Such approaches can …

A practical method for the synthesis of 15N-labeled azines with a high degree of isotopic
enrichment is described. Activation of azine heterocycles with an electron-deficient arene …

Hyperpolarisation methods that premagnetise agents such as pyruvate are currently
receiving significant attention because they produce sensitivity gains that allow disease …

In this review, we present the physical principles of the SABRE (Signal Amplification By
Reversible Exchange) method. SABRE is a promising hyperpolarization technique that …

Hyperpolarization turns weak nuclear magnetic resonance (NMR) and magnetic resonance
imaging (MRI) responses into strong signals, so normally impractical measurements are …

Signal amplification by reversible exchange (SABRE) turns typically weak magnetic
resonance responses into strong signals making previously impractical measurements …

Signal Amplification by Reversible Exchange (SABRE) is a fast and convenient NMR
hyperpolarization method that uses cheap and readily available para-hydrogen as a …

α-Ketoglutarate is a key biomolecule involved in a number of metabolic pathways─ most
notably the TCA cycle. Abnormal α-ketoglutarate metabolism has also been linked with …