Familial hypercholesterolaemia is the most commonly encountered genetic condition that
predisposes individuals to premature cardiovascular disease. Nevertheless, most patients …

The current review provides a literature overview of epigenetic modifications in lipid
metabolism and other lipid-related phenotypes and diseases focusing on EWAS of DNA …

Background Cells can be primed by external stimuli to obtain a long-term epigenetic
memory. We hypothesize that long-term exposure to elevated blood lipids can prime …

Background The discovery of robust and trans-ethnically replicated DNA methylation
markers of metabolic phenotypes, has hinted at a potential role of epigenetic mechanisms in …

Background: Autosomal dominant hypercholesterolemia (ADH) is due to deleterious
variants in LDLR, APOB, or PCSK9 genes. Double heterozygote for these genes induces a …

Significance: The number of people suffering from diabetes worldwide is steadily rising.
Complications from diabetes, including cardiovascular and renal disease, contribute to the …

The prevalence of pediatric obesity is rising rapidly worldwide, and “omic” approaches are
helpful in investigating the molecular pathophysiology of obesity. This work aims to identify …

“Si el destino es importante, el viaje lo es aún más”. Ha sido un camino largo e intenso en el
que he aprendido mucho y he crecido a nivel formativo y emocional, tropezando, cayendo y …

ABCA1 is central to reverse cholesterol transport; its transcription is regulated by LXRs (liver
X receptors) in response to intracellular cholesterol. 26 Nelson et al27 analyzed the …

Changes in plasma low-density lipoprotein cholesterol (LDL-c) levels relate to a high risk of
developing some common and complex diseases. LDL-c, as a quantitative trait, is …