The Western diet is a modern dietary pattern characterized by high intakes of pre-packaged
foods, refined grains, red meat, processed meat, high-sugar drinks, candy, sweets, fried …

Dysregulating cellular metabolism is one of the emerging cancer hallmarks. Mitochondria
are essential organelles responsible for numerous physiologic processes, such as energy …

GCN2 (general control nonderepessible 2) is an eIF2α kinase responsible for entirely
rewiring the metabolism of cells when they are put under amino acid starvation stress …

There is now a consensus that mitochondria are important tumor drivers, sophisticated
biological machines that can engender a panoply of key disease traits. How this happens …

Background The inner membrane mitochondrial protein (IMMT) is a central unit of the
mitochondrial contact site and cristae organizing system (MICOS). While researchers …

Radiation resistance is the leading cause of radiotherapy failure in patients with cancer.
Enhanced DNA damage repair is the main reason for cancer cells to develop resistance to …

Changes in metabolism are a hallmark of cancer, but molecular signatures of altered
bioenergetics to aid in clinical decision-making do not currently exist. We recently identified …

Tumor cells voraciously consume nutrients from their environment to facilitate rapid
proliferation, necessitating effective strategies to manage nutrient scarcity during tumor …

Kidney renal clear cell carcinoma (KIRC) accounts for approximately 75% of all renal
cancers. The prognosis for patients with metastatic KIRC is poor, with less than 10 …

The capacity of cancer cells to migrate from a primary tumor, disseminate throughout the
body, and eventually establish secondary tumors is a fundamental aspect of metastasis. A …