Genes and translated open reading frames (ORFs) that emerged de novo from previously
non-coding sequences provide species with opportunities for adaptation. When aberrantly …

Long non-coding RNA (lncRNA) was originally defined as the representative of the non-
coding RNAs and unable to encode. However, recent reports suggest that some lncRNAs …

To the Editor—Ribosome profiling (Ribo-seq) has extended our understanding of the
translational 'vocabulary'of the human genome, uncovering thousands of open reading …

Abstract Ribosome profiling (Ribo-Seq) has proven transformative for our understanding of
the human genome and proteome by illuminating thousands of noncanonical sites of …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Long non-coding RNAs (lncRNAs) were originally defined as non-coding RNAs (ncRNAs)
which lack protein-coding ability. However, with the emergence of technologies such as …

There is increasing evidence that long noncoding RNAs (lncRNAs) are among the main
regulatory factors of stem cell maintenance and differentiation. They act through various …

The extensively activated Notch signaling pathway in pancreatic cancer cells is important in
carcinogenesis, chemoresistance, and recurrence. Targeting this pathway is a promising …

Over the last decade, tens of thousands of new long non-coding RNAs (lncRNAs) have been
identified in the human genome. Nevertheless, except for a handful of genes, the genetic …

With significant advances in analytical technologies, research in the field of cancer
immunotherapy, such as adoptive T cell therapy, cancer vaccine, and immune checkpoint …