The 18 kDa translocator protein (TSPO) is a highly conserved protein located in the outer
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …

Abstract The translocator protein (18 kDa)(TSPO) is localized primarily in the outer
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …

Photodynamic therapy (PDT), a treatment for cancer and for certain benign conditions,
utilizes a photosensitizer and light to produce reactive oxygen in cells. PDT is primarily …

The permeability transition (PT) denotes an increase of the mitochondrial inner membrane
permeability to solutes with molecular masses up to about 1500 Da. It is presumed to be …

Abstract Translocator Protein 18 kDa (TSPO), previously named Peripheral Benzodiazepine
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …

A little over 100 years ago, Raab reported the killing of the microorganism paramecia with
the combination of acridine and light. The importance of oxygen in the process was …

The mitochondrion is well known for its key role in energy transduction. However, it is less
well appreciated that it is also a focal point of iron metabolism. Iron is needed not only for …

For over 15 years, the peripheral benzodiazepine receptor (PBR), recently named
translocator protein 18 kDa (TSPO) has been studied as a biomarker of reactive gliosis and …

The mitochondrial benzodiazepine receptor (mBzR) has been solubilized with retention of
reversible ligand binding, and the associated subunits were characterized. mBzR comprises …

The mitochondrial permeability transition pore is a high conductance channel whose
opening leads to an increase of mitochondrial inner membrane permeability to solutes with …