The role of prostaglandins in different types of cancer

Á Jara-Gutiérrez, V Baladrón - Cells, 2021 - mdpi.com
The prostaglandins constitute a family of lipids of 20 carbon atoms that derive from
polyunsaturated fatty acids such as arachidonic acid. Traditionally, prostaglandins have …

[PDF][PDF] Prostaglandin pathways: opportunities for cancer prevention and therapy

Q Wang, RJ Morris, AM Bode, T Zhang - Cancer research, 2022 - AACR
Because of profound effects observed in carcinogenesis, prostaglandins (PGs),
prostaglandin-endoperoxide synthases, and PG receptors are implicated in cancer …

The roles of the COX2/PGE2/EP axis in therapeutic resistance

D Tong, Q Liu, L Wang, Q Xie, J Pang, Y Huang… - Cancer and Metastasis …, 2018 - Springer
Therapeutic resistance has been and remains to be the major challenge in developing
successful treatments for different cancers and therefore, understanding the underlying …

Gold nanorod embedded reduction responsive block copolymer micelle-triggered drug delivery combined with photothermal ablation for targeted cancer therapy

S Parida, C Maiti, Y Rajesh, KK Dey, I Pal… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Background Gold nanorods, by virtue of surface plasmon resonance, convert incident light
energy (NIR) into heat energy which induces hyperthermia. We designed unique …

Inactivation of PI3-K/Akt and reduction of SP1 and p65 expression increase the effect of solamargine on suppressing EP4 expression in human lung cancer cells

YQ Chen, Q Tang, JJ Wu, F Zheng, LJ Yang… - Journal of Experimental …, 2015 - Springer
Background Lung cancer is the most common cause of cancer-related deaths worldwide.
Natural phytochemicals from traditional medicinal plants such as solamargine have been …

Pharmacology of grapiprant, a novel EP 4 antagonist: receptor binding, efficacy in a rodent postoperative pain model, and a dose estimation for controlling pain in …

A Nagahisa, T Okumura - Journal of veterinary pharmacology …, 2017 - Wiley Online Library
Grapiprant is an analgesic and anti‐inflammatory drug in the piprant class that was
approved in March 2016 by FDA's Center for Veterinary Medicine for the control of pain and …

Targeting EP 4 downstream c‐Jun through ERK 1/2‐mediated reduction of DNMT 1 reveals novel mechanism of solamargine‐inhibited growth of lung cancer cells

Y Chen, Q Tang, Q Xiao, LJ Yang… - Journal of Cellular and …, 2017 - Wiley Online Library
Lung cancer is the most common cancer and the leading cause of cancer deaths worldwide.
We previously showed that solamargine, one natural phytochemicals from traditional plants …

Prostaglandin E2 promotes pathological retinal neovascularisation via EP4R-EGFR-Gab1-AKT signaling pathway

T Xie, Z Zhang, Y Cui, Y Shu, Y Liu, J Zou… - Experimental Eye …, 2021 - Elsevier
Proliferative retinopathies, such as proliferative diabetic retinopathy (PDR) and retinopathy
of prematurity (ROP) are major causes of visual impairment and blindness in industrialized …

Identification of RAB2A and PRDX1 as the potential biomarkers for oral squamous cell carcinoma using mass spectrometry-based comparative proteomic approach

KK Dey, I Pal, R Bharti, G Dey, BNP Kumar, S Rajput… - Tumor Biology, 2015 - Springer
Despite the recent advances in diagnostic and therapeutic strategies, oral squamous cell
carcinoma (OSCC) remains a major health burden. Protein biomarker discovery for early …

Quantification of grapiprant and its stability testing under changing environmental conditions

P Gumułka, M Tarsa, M Dąbrowska, M Starek - Biomedicines, 2022 - mdpi.com
Grapiprant is a new analgesic and anti-inflammatory drug belonging to the piprant class,
approved in 2016 by the FDA Veterinary Medicine Center for the treatment of pain and …