The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits,
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …

The Mediator complex is a multi-subunit assembly that appears to be required for regulating
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …

Non-small-cell lung cancer is often diagnosed at the metastatic stage, with median survival
of just 1 year. The identification of driver mutations in the epidermal growth factor receptor …

Mediator is a multiprotein complex that is required for gene transcription by RNA polymerase
II. Multiple subunits of the complex show specificity in relaying information from signals and …

The ERK-regulated ternary complex factors (TCFs) act with the transcription factor serum
response factor (SRF) to activate mitogen-induced transcription. However, the extent of their …

Although we have made significant progress, we still possess a limited understanding of
how genomic and epigenomic information directs gene expression programs through …

Little is known about biological significance of ELK1, a transcriptional factor that activates
downstream targets including c-fos proto-oncogene, in bladder cancer. Recent preclinical …

Mediator complex (MED) is an evolutionarily conserved multiprotein, fundamental for growth
and survival of all cells. In eukaryotes, the mRNA transcription is dependent on RNA …

Mediator complex is a molecular hub integrating signaling, transcription factors, and RNA
polymerase II (RNAPII) machinery. Mediator MED23 is involved in adipogenesis and smooth …

The nucleus controls cell growth and division through coordinated interactions between
nuclear proteins and chromatin. Mutations that impair nuclear protein association with …