Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors

I Jurado-Martín, M Sainz-Mejías… - International journal of …, 2021 - mdpi.com
Pseudomonas aeruginosa is a dominant pathogen in people with cystic fibrosis (CF)
contributing to morbidity and mortality. Its tremendous ability to adapt greatly facilitates its …

Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis

E Rossi, R La Rosa, JA Bartell, RL Marvig… - Nature Reviews …, 2021 - nature.com
Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

Outer membrane permeability: Antimicrobials and diverse nutrients bypass porins in Pseudomonas aeruginosa

J Ude, V Tripathi, JM Buyck… - Proceedings of the …, 2021 - National Acad Sciences
Gram-negative bacterial pathogens have an outer membrane that restricts entry of
molecules into the cell. Water-filled protein channels in the outer membrane, so-called …

How Bacterial Adaptation to Cystic Fibrosis Environment Shapes Interactions Between Pseudomonas aeruginosa and Staphylococcus aureus

L Camus, P Briaud, F Vandenesch… - Frontiers in …, 2021 - frontiersin.org
Pseudomonas aeruginosa and Staphylococcus aureus are the two most prevalent bacteria
species in the lungs of cystic fibrosis (CF) patients and are associated with poor clinical …

Compensatory evolution of Pseudomonas aeruginosa's slow growth phenotype suggests mechanisms of adaptation in cystic fibrosis

R La Rosa, E Rossi, AM Feist, HK Johansen… - Nature …, 2021 - nature.com
Long-term infection of the airways of cystic fibrosis patients with Pseudomonas aeruginosa
is often accompanied by a reduction in bacterial growth rate. This reduction has been …

The structure–function relationship of Pseudomonas aeruginosa in infections and its influence on the microenvironment

M Lichtenberg, TH Jakobsen, M Kühl… - FEMS microbiology …, 2022 - academic.oup.com
Pseudomonas aeruginosa is a human pathogen associated with both acute and chronic
infections. While intensively studied, the basic mechanisms enabling the long-term survival …

From genotype to phenotype: adaptations of Pseudomonas aeruginosa to the cystic fibrosis environment

L Camus, F Vandenesch, K Moreau - Microbial genomics, 2021 - microbiologyresearch.org
Pseudomonas aeruginosa is one of the main microbial species colonizing the lungs of cystic
fibrosis patients and is responsible for the decline in respiratory function. Despite the hostile …

Contextual flexibility in Pseudomonas aeruginosa central carbon metabolism during growth in single carbon sources

SK Dolan, M Kohlstedt, S Trigg, P Vallejo Ramirez… - MBio, 2020 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic human pathogen, particularly noted for
causing infections in the lungs of people with cystic fibrosis (CF). Previous studies have …

Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa

A Simonis, C Kreer, A Albus, K Rox, B Yuan… - Cell, 2023 - cell.com
Drug-resistant Pseudomonas aeruginosa (PA) poses an emerging threat to human health
with urgent need for alternative therapeutic approaches. Here, we deciphered the B cell and …

Models using native tracheobronchial mucus in the context of pulmonary drug delivery research: composition, structure and barrier properties

BC Huck, X Murgia, S Frisch, M Hittinger… - Advanced Drug Delivery …, 2022 - Elsevier
Mucus covers all wet epithelia and acts as a protective barrier. In the airways of the lungs,
the viscoelastic mucus meshwork entraps and clears inhaled materials and efficiently …