Two cases of Hailey‐Hailey disease effectively treated with apremilast and a review of reported cases

A Yoto, T Makino, M Mizawa, Y Matsui… - The Journal of …, 2021 - Wiley Online Library
Hailey‐Hailey disease (HHD) is an autosomal dominant genetic disease caused by a
mutation of the ATP2C1 gene. Corticosteroids, antibiotics or cyclosporine have been …

Evolving utility of apremilast in dermatological disorders for off‐label indications

H Mehta, A Sharma, S Dogra - Clinical and Experimental …, 2022 - academic.oup.com
Apremilast, a small molecule that acts by inhibition of the phosphodiesterase‐4 enzyme, has
been approved by the US Food and Drug Administration for the management of psoriatic …

Treatment of Hailey–Hailey disease with biologics and small-molecule inhibitors: a systematic review

W Liu, X Xue, S Li - Clinical and Experimental Dermatology, 2025 - academic.oup.com
Hailey–Hailey disease (HHD) is a rare genetic dermatosis characterized by recurrent flaccid
vesicles and blisters on erythematous skin in friction areas. The disease follows a chronic …

Case Report: A Case of Hailey–Hailey Disease Mimicking Condyloma Acuminatum and a Novel Splice-Site Mutation of ATP2C1 Gene

Y Dai, L Yu, Y Wang, M Gao, P Wang - Frontiers in Genetics, 2021 - frontiersin.org
Hailey–Hailey disease (HHD) is a rare autosomal-dominant blistering disorder
characterized by recurrent vesicular and erosive lesions at intertriginous sites. We described …

[PDF][PDF] Apremilast in benign chronic pemphigus (Hailey-Hailey disease)

C Riquelme-Mc Loughlin, P Iranzo… - Clin Exp Dermatol, 2020 - researchgate.net
Hailey–Hailey disease (HHD), is an autosomal dominant genodermatosis with a chronic and
refractory clinical course that greatly affects patient quality of life (QoL). Recently, the …

Case report: Difference in outcomes between two cases of Hailey-Hailey disease treated with apremilast

M Yamaga, T Miyauchi, JT Peh, S Itamoto, Y Mai… - Frontiers in …, 2022 - frontiersin.org
Hailey-Hailey disease (HHD) is a rare autosomal dominant acantholytic dermatosis clinically
characterized by recurrent erythematous plaques and erosions mainly on the intertriginous …

Phosphodiesterase-4-Inhibitoren in der Dermatologie

MF Schmidt, N Albuscheit, AS Yazdi - Die Dermatologie, 2024 - Springer
Zusammenfassung Hintergrund Chronisch inflammatorische Hauterkrankungen haben
einen hohen gesellschaftlichen und medizinischen Stellenwert und bedürfen einer …

An In-depth Review of the Off-label Use of Apremilast in Dermatology

AK Bubna, V Viplav - Journal of Pharmacology and …, 2024 - journals.sagepub.com
Background Apremilast is a phosphodiesterase-4 (PDE-4) inhibitor approved by the US-
Food and Drug Administration (US-FDA) for the management of adult patients with plaque …

Inherited acantholytic disorders

M Zamiri, CS Munro - Rook's Textbook of Dermatology, Ninth …, 2016 - Wiley Online Library
Darier disease (DD) and Hailey–Hailey disease (HHD) are autosomal dominant disorders
characterized by epidermal acantholysis. They have a similar molecular pathogenesis, with …

Successful Use of Apremilast in Treatment of Refractory Hailey Hailey Disease

R Kaur, I Agrawal, S Sood - Indian Dermatology Online Journal, 2024 - journals.lww.com
Letter to the Editor of HHD. The patient's laboratory investigations did not reveal any notable
abnormalities. Considering the patient's extensive use of medications in the past, which had …