Thanks to the development of new, more potent and selective immunosuppressive drugs
together with advances in surgical techniques, organ transplantation has emerged from an …

Pancreatic cancer (PC) is the fourth most common cause of death among all cancers. Poor
prognosis of PC may be caused by a prevalence of cancer stem cells (CSCs). CSCs are a …

Background CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is
phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and …

The chemokine receptor CXCR4 and its cognate ligand CXCL12 recently have been
proposed to regulate the directional trafficking and invasion of breast cancer cells to sites of …

Stem cell transplantation at the time of acute myocardial infarction (AMI) improves cardiac
function. Whether the improved cardiac function results from regeneration of cardiac …

Chemokine networks regulate a variety of cellular, physiological, and immune processes.
These normal functions can become appropriated by cancer cells to facilitate a more …

In this study, we have evaluated 11 pancreatic tumor cell lines and tumor cells from surgical
samples of patients with pancreatic adenocarcinoma for expression of the chemokine …

The maintenance of bone marrow stromal stem cells (BMSSCs) is tightly controlled by the
local microenvironment and by autocrine regulatory factors secreted by BMSSCs. To identify …

The chemokine CXCL12 (SDF-1) and its cognate receptor CXCR4 were first identified in the
context of trafficking and homeostasis of immune cells, such as T lymphocytes …

Chemokines are chemoattractants that can regulate cell movement and adhesion. SDF-1
[stromal cell-derived factor-1 (SDF-1)] is a homeostatic CXC chemokine. SDF-1 and its …