Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …

The molecular mechanisms of sarcomere proteins underlie the contractile function of the
heart. Although our understanding of the sarcomere has grown tremendously, the focus has …

We compared commonly used BAPTA-derived chemical Ca 2+ dyes (fura2, Fluo-4, and
Rhod-2) with a newer genetically encoded indicator (R-GECO) in single cell models of the …

BACKGROUND: Diastolic dysfunction is central to diseases such as heart failure with
preserved ejection fraction and hypertrophic cardiomyopathy (HCM). However, therapies …

Hypertrophic cardiomyopathy (HCM) is frequently caused by mutations in the cardiac
myosin binding protein-C (cMyBP-C) encoding gene MYBPC3. In the Netherlands …

A moderate degree of lead intoxication was observed in male rats after repeated
intraperitoneal injections with two doses of lead acetate three times a week during 5 (12.5 …

Type 1 diabetes (T1D) leads to ischemic heart disease and diabetic cardiomyopathy. We
tested the hypothesis that T1D differently affects the contractile function of the left and right …

In this study, we synthesized and evaluated new photoswitchable ligands for the beta-
adrenergic receptors β 1-AR and β 2-AR, applying an azologization strategy to the first …

Cardiomyocytes contract keeping their sarcomere length (SL) close to optimal values for
force generation. Transmural heterogeneity in SL across the ventricular wall coordinates the …

Background: The left and right ventricles of the human heart differ in embryology, shape,
thickness, and function. Ventricular dyssynchrony often occurs in cases of heart failure. Our …