The extracellular matrix (ECM) is the complex meshwork of proteins and glycans that forms
the scaffold that surrounds and supports cells. It exerts key roles in all aspects of metazoan …

The extracellular matrix (ECM) serves diverse functions and is a major component of the
cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a …

The term matricellular proteins describes a family of structurally unrelated extracellular
macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue …

A large body of evidence supports the involvement of heparan sulfate (HS) proteoglycans in
physiological processes such as development and diseases including cancer and …

Scarring and tissue fibrosis represent a significant source of morbidity in the United States.
Despite considerable research focused on elucidating the mechanisms underlying …

Full-thickness rotator cuff tears are one of the most common causes of shoulder pain in
people over the age of 65. High retear rates and poor functional outcomes are common after …

Proteoglycans consist of a protein core with one or more covalently attached
glycosaminoglycan (GAG) side chains and have multiple roles in the initiation and …

The small leucine rich repeat proteoglycans are major components of the cornea. Lumican,
keratocan, decorin, biglycan and osteoglycin are present throughout the adult corneal …

La matriz extracelular (MEC) representa una red tridimensional que engloba todos los
órganos, tejidos y células del organismo. Constituye un filtro biofísico de protección …

Idiopathic pulmonary fibrosis (IPF) is the most common interstitial lung disease with a fatal
prognosis. Over the last decade, the concepts in pathobiology of pulmonary fibrosis have …