Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections

P Zimmermann, N Curtis - Archives of disease in childhood, 2021 - adc.bmj.com
In contrast to other respiratory viruses, children have less severe symptoms when infected
with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this …

Role of toll‐like receptors in modulation of cytokine storm signaling in SARS‐CoV‐2‐induced COVID‐19

M Manik, RK Singh - Journal of medical virology, 2022 - Wiley Online Library
Balanced immune regulation is crucial for recognizing an invading pathogen, its killing, and
elimination. Toll‐like receptors (TLRs) are the key regulators of the innate immune system. It …

[HTML][HTML] COVID-19 mortality risk correlates inversely with vitamin D3 status, and a mortality rate close to zero could theoretically be achieved at 50 ng/mL 25 (OH) D3 …

L Borsche, B Glauner, J von Mendel - Nutrients, 2021 - mdpi.com
Background: Open Access Editor's Choice Systematic Review COVID-19 Mortality Risk
Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could …

[HTML][HTML] Is melatonin the cornucopia of the 21st century?

N Ferlazzo, G Andolina, A Cannata, MG Costanzo… - Antioxidants, 2020 - mdpi.com
Melatonin, an indoleamine hormone produced and secreted at night by pinealocytes and
extra-pineal cells, plays an important role in timing circadian rhythms (24-h internal clock) …

Heavy metal and metalloid-induced reproductive toxicity

AG Mukherjee, UR Wanjari, K Renu, B Vellingiri… - Environmental …, 2022 - Elsevier
Heavy metals and metalloid exposure are among the most common factors responsible for
reproductive toxicity in human beings. Several studies have indicated that numerous metals …

[HTML][HTML] A basic review of the preliminary evidence that COVID-19 risk and severity is increased in vitamin D deficiency

LL Benskin - Frontiers in public health, 2020 - frontiersin.org
As the world's attention has been riveted upon the growing COVID-19 pandemic, many
researchers have written brief reports supporting the hypothesis that vitamin D deficiency is …

Effects of vitamin D on COVID-19 infection and prognosis: a systematic review

H Yisak, A Ewunetei, B Kefale, M Mamuye… - … and healthcare policy, 2021 - Taylor & Francis
Introduction Vitamin D status is related to risks of influenza and respiratory tract infections.
Vitamin D has direct antiviral effects primarily against enveloped viruses, and coronavirus is …

[HTML][HTML] Melatonin and multiple sclerosis: Antioxidant, anti-inflammatory and immunomodulator mechanism of action

A Muñoz-Jurado, BM Escribano… - …, 2022 - Springer
Background Melatonin is an indole hormone secreted primarily by the pineal gland that
showing anti-oxidant, anti-inflammatory and anti-apoptotic capacity. It can play an important …

[HTML][HTML] Cellular and molecular pathways of COVID-19 and potential points of therapeutic intervention

JP Hussman - Frontiers in pharmacology, 2020 - frontiersin.org
With the objective of linking early findings relating to the novel SARS-CoV-2 coronavirus
with potentially informative findings from prior research literature and to promote …

[HTML][HTML] Combining a convolutional neural network with autoencoders to predict the survival chance of COVID-19 patients

F Khozeimeh, D Sharifrazi, NH Izadi, JH Joloudari… - Scientific Reports, 2021 - nature.com
COVID-19 has caused many deaths worldwide. The automation of the diagnosis of this virus
is highly desired. Convolutional neural networks (CNNs) have shown outstanding …