The extended granin family: structure, function, and biomedical implications

A Bartolomucci, R Possenti, SK Mahata… - Endocrine …, 2011 - academic.oup.com
The chromogranins (chromogranin A and chromogranin B), secretogranins (secretogranin II
and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) …

Role of catestatin in the cardiovascular system and metabolic disorders

E Zalewska, P Kmieć, K Sworczak - Frontiers in cardiovascular …, 2022 - frontiersin.org
Catestatin is a multifunctional peptide that is involved in the regulation of the cardiovascular
and immune systems as well as metabolic homeostatis. It mitigates detrimental, excessive …

Chromogranin A and its fragments in cardiovascular, immunometabolic, and cancer regulation

SK Mahata, A Corti - Annals of the New York Academy of …, 2019 - Wiley Online Library
Chromogranin A (CgA)—the index member of the chromogranin/secretogranin secretory
protein family—is ubiquitously distributed in endocrine, neuroendocrine, and immune cells …

Biological function and clinical relevance of chromogranin A and derived peptides

MA D'amico, B Ghinassi, P Izzicupo… - Endocrine …, 2014 - ec.bioscientifica.com
Chromogranin A (CgA (CHGA)) is the major soluble protein co-stored and co-released with
catecholamines and can function as a pro-hormone by giving rise to several bioactive …

Catestatin as a biomarker of cardiovascular diseases: a clinical perspective

J Bozic, M Kumric, T Ticinovic Kurir, H Urlic… - Biomedicines, 2021 - mdpi.com
Accounting for almost one-third of the global mortality, cardiovascular diseases (CVDs)
represent a major global health issue. Emerging data suggest that most of the well …

Sympathetic nervous system: role in hypertension and in chronic kidney disease

G Grassi, S Bertoli, G Seravalle - Current opinion in nephrology …, 2012 - journals.lww.com
Sympathetic nervous system: role in hypertension and in chro... : Current Opinion in
Nephrology and Hypertension Sympathetic nervous system: role in hypertension and in chronic …

The antihypertensive chromogranin a peptide catestatin acts as a novel endocrine/paracrine modulator of cardiac inotropism and lusitropism

T Angelone, AM Quintieri, BK Brar… - …, 2008 - academic.oup.com
Circulating levels of catestatin (Cts; human chromogranin A352–372) decrease in the
plasma of patients with essential hypertension. Genetic ablation of the chromogranin A …

Reprint of: catestatin: a multifunctional peptide from Chromogranin A

SK Mahata, M Mahata, MM Fung, DT O'Connor - Regulatory peptides, 2010 - Elsevier
In 1997, we identified a novel peptide, catestatin (CST: bovine chromogranin A [CHGA] 344–
364: RSMRLSFRARGYGFRGPGLQL; human CHGA352–372 …

Immunosuppression of macrophages underlies the cardioprotective effects of CST (Catestatin)

W Ying, K Tang, E Avolio, JM Schilling, T Pasqua… - …, 2021 - Am Heart Assoc
Hypertension is associated with inflammation and excessive production of catecholamines.
Hypertensive patients have reduced plasma levels of CST (catestatin)—a bioactive …

Chromogranins A and B and secretogranin II: evolutionary and functional aspects

M Montero‐Hadjadje, S Vaingankar, S Elias… - Acta …, 2008 - Wiley Online Library
Chromogranins/secretogranins or granins are a class of acidic, secretory proteins that occur
in endocrine, neuroendocrine, and neuronal cells. Granins are the precursors of several …