Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection
J Guenthoer, M Lilly, TN Starr… - Proceedings of the …, 2023 - National Acad Sciences
The antiviral benefit of antibodies can be compromised by viral escape especially for rapidly
evolving viruses. Therefore, durable, effective antibodies must be both broad and potent to …
evolving viruses. Therefore, durable, effective antibodies must be both broad and potent to …
Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates
Germline-targeting immunogens hold promise for initiating the induction of broadly
neutralizing antibodies (bnAbs) to HIV and other pathogens. However, antibody-antigen …
neutralizing antibodies (bnAbs) to HIV and other pathogens. However, antibody-antigen …
Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies
Vaccination strategies aimed at maturing broadly neutralizing antibodies (bnAbs) from naïve
precursors are hindered by unusual features that characterize these Abs, including …
precursors are hindered by unusual features that characterize these Abs, including …
Role of surface glycans in enveloped RNA virus infections: A structural perspective
B Pandey, A Chatterjee… - … Structure, Function, and …, 2023 - Wiley Online Library
Enveloped RNA viruses have been causative agents of major pandemic outbreaks in the
recent past. Glycans present on these virus surface proteins are critical for multiple …
recent past. Glycans present on these virus surface proteins are critical for multiple …
Higher HIV-1 Env gp120-specific antibody-dependent cellular cytotoxicity (ADCC) activity is associated with lower levels of defective HIV-1 provirus
R Yucha, ML Litchford, CS Fish, ZA Yaffe… - Viruses, 2023 - mdpi.com
A cure for HIV-1 (HIV) remains unrealized due to a reservoir of latently infected cells that
persist during antiretroviral therapy (ART), with reservoir size associated with adverse health …
persist during antiretroviral therapy (ART), with reservoir size associated with adverse health …
Epitope binning of monoclonal and polyclonal antibodies by biolayer interferometry
K Nagashima, JJ Mousa - Computational Vaccine Design, 2023 - Springer
Understanding the epitopes of antibodies elicited by infection and vaccination is often useful
in immunogen design. In this chapter, we describe biolayer interferometry (BLI)-based …
in immunogen design. In this chapter, we describe biolayer interferometry (BLI)-based …
Complementary Roles of Antibody Heavy and Light Chain Somatic Hypermutation in Conferring Breadth and Potency to the HIV-1-Specific CAP256-VRC26 bNAb …
Some HIV-infected people develop broadly neutralizing antibodies (bNAbs) that block many
diverse, unrelated strains of HIV from infecting target cells and, through passive …
diverse, unrelated strains of HIV from infecting target cells and, through passive …