Role of nanotechnology in taste masking: recent updates

V Vishvakarma, M Kaur, M Nagpal… - Current Drug Research …, 2023 - benthamdirect.com
One of the important parameters in the case of dosage form is taste. Most of the drugs
available in oral dosage form have an unpleasant taste which leads to patient incompliance …

Amino Acid Bitterness: Characterization and Suppression

CP Harmon, OM Ahmed… - Journal of Agricultural and …, 2024 - ACS Publications
Amino acids are necessary for life, and many must be consumed because they cannot be
endogenously synthesized. Typically, we eat them as proteins and peptides, which have …

Topical application of a P2X2/P2X3 purine receptor inhibitor suppresses the bitter taste of medicines and other taste qualities

LJ Flammer, H Ellis, N Rivers, L Caronia… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Many medications taste intensely bitter. The innate
aversion to bitterness affects medical compliance, especially in children. There is a clear …

Variation in TAS2R receptor genes explains differential bitterness of two common antibiotics

AA Nolden, JE Hayes, EL Feeney - Frontiers in Genetics, 2022 - frontiersin.org
For pharmaceuticals to deliver their full benefits with maximum efficacy, patients need to
follow recommended dosing schedules, in terms of amount and frequency. Unfortunately …

Paxlovid mouth likely is mediated by activation of the TAS2R1 bitter receptor by nirmatrelvir

L Caronia, R Xi, RF Margolskee, P Jiang - Biochemical and Biophysical …, 2023 - Elsevier
Abstract Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has remained a public health threat since late 2019. Among …

Pseudo-Taste Cells Derived from Rat Taste and Non-Taste Tissues: Implications for Cultured Taste Cell-Based Biosensors

Z Chen, HY Chung - Journal of Agricultural and Food Chemistry, 2022 - ACS Publications
Although the technique for taste cell culture has been reported, cultured taste cells have
remained poorly validated. This study systematically compared the cultured cells derived …

[HTML][HTML] Worldwide study of the taste of bitter medicines and their modifiers

H Nguyen, C Lin, K Bell, A Huang, M Hannum… - bioRxiv, 2024 - ncbi.nlm.nih.gov
The bitter taste of medicines hinders patient compliance, but not everyone experiences
these difficulties because people worldwide differ in their bitterness perception. To better …

Anti-HIV drugs lopinavir/ritonavir activate bitter taste receptors

S Chen, X Zhou, Y Lu, K Xu, J Wen, M Cui - Chemical Senses, 2023 - academic.oup.com
Lopinavir and ritonavir (LPV/r) are the primary anti-human immunodeficiency virus (HIV)
drugs recommended by the World Health Organization for treating children aged 3 years …

Biopharmaceutics of excipients in paediatric medicines

DL Andrews - 2022 - discovery.ucl.ac.uk
Children require palatable medicines. Excipients can improve the acceptability of a
formulation, enabling children to take their dose as prescribed to achieve therapeutic …

COMPOSITIONS AND METHODS OF AMELIORATING AVERSIVENESS OF AVERSIVE STIMULI BY INHIBITION OF PURINERGIC RECEPTORS

P Jiang, L Flammer, P Breslin - US Patent App. 18/698,524, 2024 - freepatentsonline.com
Provided herein are compositions and methods of modulating an aversive taste of active
pharmaceutical ingredients (API) in a medicament, nutrient, and/or a dietary supplement via …