Epilepsy is the fourth most common neurological disorder, but current treatment options
provide limited efficacy and carry the potential for problematic adverse effects. There is an …

Deep brain stimulation (DBS) is a promising technique to relieve the symptoms in patients
with intractable seizures. Although the DBS therapy for seizure suppression dates back …

Patients with idiopathic generalised epilepsy (IGE) typically have normal conventional
magnetic resonance imaging (MRI), hence diagnosis based on MRI is challenging …

Absence seizures usually occur in dysfunctional neural networks. Thalamic feed-forward
inhibition and feed-back inhibition are the two most critical microcircuits, which can be …

Background Significant knowledge gap exists on vagus nerve stimulation (VNS) efficacy and
tolerability in medically refractory absence seizures (MRAS). This retrospective review of …

In this paper, we establish a cortical-thalamic-basal ganglia mean-field computational
network that includes a newly determined direct glutamatergic thalamic-subthalamic …

Vigabatrin increases GABA concentrations by inhibiting GABA transaminase. In previous
studies, it was shown that vigabatrin increases the incidence of Spike and Wave Discharges …

Absence seizures are not only associated with abnormal interactions in basal
gangliacorticothalamic (BGCT) circuits, but are also influenced by glial functions. By …

The focus of this paper is to investigate the dynamics of seizure activities by using the
Epileptor coupled model. Based on the coexistence of seizure-like event (SLE), refractory …

Absence epilepsy, characterized by transient loss of awareness and bilaterally synchronous
2–4 Hz spike and wave discharges (SWDs) on electroencephalography (EEG) during …