Lipid and immune pathways are crucial in the pathophysiology of metabolic and
cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to …

Controlled immune responses to infection and injury involve complex molecular signalling
networks with coordinated and often opposing actions. Eicosanoids and related bioactive …

Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …

Leukotrienes, a class of arachidonic acid–derived bioactive molecules, are known as
mediators of allergic and inflammatory reactions and considered to be important drug …

Leukotrienes (LTs) are lipid mediators that play pivotal roles in acute and chronic
inflammation and allergic diseases. They exert their biological effects by binding to specific …

Gluten-related disorders include distinct disease entities, namely celiac disease, wheat-
associated allergy and non-celiac gluten/wheat sensitivity. Despite having in common the …

The endogenous ligands for the LT, lipoxin (LX) and oxoeicosanoid receptors are bioactive
products produced by the action of the lipoxygenase family of enzymes. The LT receptors …

Interaction of mast cells (MCs) with fibroblasts is essential for MC maturation within tissue
microenvironments, although the underlying mechanism is incompletely understood …

Abstract Leukotriene B 4 (LTB 4), a lipid mediator produced from arachidonic acid, is a
chemoattractant for inflammatory leukocytes. We identified two receptors for LTB 4, the high …

Abstract Leukotriene B4 (LTB4) is a potent inflammatory mediator derived from arachidonic
acid. Two G protein-coupled receptors for LTB4 have been identified: a high-affinity receptor …