Neuroinflammation is involved in the onset or progression of various neurodegenerative
diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage …

State-of-the-art tissue-clearing methods provide subcellular-level optical access to intact
tissues from individual organs and even to some entire mammals. When combined with light …

The blood brain barrier (BBB) presents a formidable challenge to the delivery of drugs into
the brain. Several strategies aim to overcome this obstacle and promote efficient and …

Cerebral blood flow (CBF) reductions in Alzheimer's disease patients and related mouse
models have been recognized for decades, but the underlying mechanisms and resulting …

The cerebral vasculature is a dense network of arteries, capillaries, and veins. Quantifying
variations of the vascular organization across individuals, brain regions, or disease models …

Tissue clearing methods enable the imaging of biological specimens without sectioning.
However, reliable and scalable analysis of large imaging datasets in three dimensions …

To continuously process neural activity underlying sensation, movement and cognition, the
CNS requires a homeostatic microenvironment that is not only enriched in nutrients to meet …

For half a century, the human brain was believed to contain about 100 billion neurons and
one trillion glial cells, with a glia: neuron ratio of 10: 1. A new counting method, the isotropic …

We have developed a single-breath-hold photoacoustic computed tomography (SBH-PACT)
system to reveal detailed angiographic structures in human breasts. SBH-PACT features a …

The mouse brain is the most extensively studied brain of all species. We performed an
exhaustive review of the literature to establish our current state of knowledge on cell …