Pyridine: the scaffolds with significant clinical diversity
The nitrogen-bearing heterocycle pyridine in its several analogous forms occupies an
important position as a precious source of clinically useful agents in the field of medicinal …
important position as a precious source of clinically useful agents in the field of medicinal …
Caspase‐3: A primary target for natural and synthetic compounds for cancer therapy
Caspases, a group of protease enzymes (cysteine proteases), exist as inactive zymogens in
the cells and execute apoptosis (programmed cell death). Caspase‐3, an executioner …
the cells and execute apoptosis (programmed cell death). Caspase‐3, an executioner …
Spectroscopic studies, antimicrobial activity, and computational investigations of hydrazone ligands endowed metal chelates
Our current efforts are aimed to synthesize 16 complexes of Co (II), Ni (II), Cu (II), and Zn (II)
metal ions from heterocyclic hydrazone ligands by condensation reaction of 2, 6 …
metal ions from heterocyclic hydrazone ligands by condensation reaction of 2, 6 …
A therapeutic journey of pyridine-based heterocyclic compounds as potent anticancer agents: a review (from 2017 to 2021)
M Alrooqi, S Khan, FA Alhumaydhi… - Anti-Cancer Agents …, 2022 - ingentaconnect.com
Pyridine derivatives are the most common and significant heterocyclic compounds, which
show their fundamental characteristics to various pharmaceutical agents and natural …
show their fundamental characteristics to various pharmaceutical agents and natural …
Flavone-based hydrazones as new tyrosinase inhibitors: Synthetic imines with emerging biological potential, SAR, molecular docking and drug-likeness studies
Targeting tyrosinase (TYR), a key enzyme responsible for melanogenesis disorders, is a
well-known approach utilized for the development of melanogenesis inhibitor. A variety of …
well-known approach utilized for the development of melanogenesis inhibitor. A variety of …
Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers
In the present study, the various 28 hybrid molecules containing hydrazone and sulfonate
moieties were synthesized and characterized by FTIR, 1H-NMR, 13C-NMR spectroscopy …
moieties were synthesized and characterized by FTIR, 1H-NMR, 13C-NMR spectroscopy …
Recent developments in mitogen activated protein kinase inhibitors as potential anticancer agents
The mitogen activated protein kinase (MAPK) belongs to group of kinase that links the
extracellular stimuli to intracellular response. The MAPK signalling pathway (RAS-RAF-MEK …
extracellular stimuli to intracellular response. The MAPK signalling pathway (RAS-RAF-MEK …
Iodinated 1, 2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents
M Krátký, K Konečná, M Brablíková, J Janoušek… - Bioorganic & Medicinal …, 2021 - Elsevier
Hydrazide-hydrazones have been described as a scaffold with antimicrobial and cytotoxic
activities as well as iodinated compounds. A resistance rate of bacterial and fungal …
activities as well as iodinated compounds. A resistance rate of bacterial and fungal …
Anticancer effect of umbelliferone on MKN-45 and MIA PaCa-2 cell lines
ÖS Aslantürk, TA Çelik - Toxicology in Vitro, 2023 - Elsevier
In this study, the anticancer activity of umbelliferone (7-hydroxycoumarin-UMB) was
investigated in MKN-45 human gastric cancer and MIA PaCa-2 human pancreatic cancer …
investigated in MKN-45 human gastric cancer and MIA PaCa-2 human pancreatic cancer …
[HTML][HTML] Synthesis and greener pastures biological study of bis-thiadiazoles as potential Covid-19 drug candidates
A novel series of bis-(Abdelhamid et al., 2017, Banerjee et al., 2018, Bharanidharan et al.,
2022) thiadiazoles was synthesized from the reaction of precursor dimethyl 2, 2′-(1, 2 …
2022) thiadiazoles was synthesized from the reaction of precursor dimethyl 2, 2′-(1, 2 …