Bacterial pore-forming toxins
Pore-forming toxins (PFTs) are widely distributed in both Gram-negative and Gram-positive
bacteria. PFTs can act as virulence factors that bacteria utilise in dissemination and host …
bacteria. PFTs can act as virulence factors that bacteria utilise in dissemination and host …
Pathogenicity and virulence of Bordetella pertussis and its adaptation to its strictly human host
T Belcher, V Dubois, A Rivera-Millot, C Locht… - Virulence, 2021 - Taylor & Francis
The highly contagious whooping cough agent Bordetella pertussis has evolved as a human-
restricted pathogen from a progenitor which also gave rise to Bordetella parapertussis and …
restricted pathogen from a progenitor which also gave rise to Bordetella parapertussis and …
Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b
MP Lenza, L Egia-Mendikute… - Nature …, 2023 - nature.com
Sialic acid-binding Ig-like lectin 15 (Siglec-15) is an immune modulator and emerging
cancer immunotherapy target. However, limited understanding of its structure and …
cancer immunotherapy target. However, limited understanding of its structure and …
Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin
Integrins are ubiquitous cell-surface heterodimers that are exploited by pathogens and
toxins, including leukotoxins that target β 2 integrins on phagocytes. The Bordetella …
toxins, including leukotoxins that target β 2 integrins on phagocytes. The Bordetella …
Bacterial toxins: Offensive, defensive, or something else altogether?
JK Rudkin, RM McLoughlin, A Preston… - Plos pathogens, 2017 - journals.plos.org
The secretion of proteins that damage host tissue is well established as integral to the
infectious processes of many bacterial pathogens. However, recent advances in our …
infectious processes of many bacterial pathogens. However, recent advances in our …
[HTML][HTML] CSMD1 regulates brain complement activity and circuit development
Complement proteins facilitate synaptic elimination during neurodevelopmental pruning, but
neural complement regulation is not well understood. CUB and Sushi Multiple Domains 1 …
neural complement regulation is not well understood. CUB and Sushi Multiple Domains 1 …
Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis
The fungal pathogen Candida albicans is linked to chronic brain diseases such as
Alzheimer's disease (AD), but the molecular basis of brain anti-Candida immunity remains …
Alzheimer's disease (AD), but the molecular basis of brain anti-Candida immunity remains …
The Fim and FhaB adhesins play a crucial role in nasal cavity infection and Bordetella pertussis transmission in a novel mouse catarrhal infection model
J Holubova, O Stanek, A Juhasz… - PLoS …, 2022 - journals.plos.org
Pulmonary infections caused by Bordetella pertussis used to be the prime cause of infant
mortality in the pre-vaccine era and mouse models of pertussis pneumonia served in …
mortality in the pre-vaccine era and mouse models of pertussis pneumonia served in …
Bordetella pertussis: new concepts in pathogenesis and treatment
NH Carbonetti - Current opinion in infectious diseases, 2016 - journals.lww.com
Bordetella pertussis: new concepts in pathogenesis and treat... : Current Opinion in Infectious
Diseases Bordetella pertussis: new concepts in pathogenesis and treatment : Current Opinion …
Diseases Bordetella pertussis: new concepts in pathogenesis and treatment : Current Opinion …
Structural basis for antibody binding to adenylate cyclase toxin reveals RTX linkers as neutralization-sensitive epitopes
JA Goldsmith, AM DiVenere, JA Maynard… - PLoS …, 2021 - journals.plos.org
RTX leukotoxins are a diverse family of prokaryotic virulence factors that are secreted by the
type 1 secretion system (T1SS) and target leukocytes to subvert host defenses. T1SS …
type 1 secretion system (T1SS) and target leukocytes to subvert host defenses. T1SS …