Chitosan coated nanostructured lipid carriers for enhanced in vivo efficacy of albendazole against Trichinella spiralis

RK Eid, DS Ashour, EA Essa, GM El Maghraby… - Carbohydrate …, 2020 - Elsevier
The study investigated chitosan coated nanostructured lipid carriers (NLCs) for oral delivery
of albendazole in treatment of trichinellosis. NLCs comprised precirol and oleic acid with …

Identification and quantification techniques of polymorphic forms-A review

JT Chambi, C Fandaruff, SL Cuffini - Journal of Pharmaceutical and …, 2024 - Elsevier
In the pharmaceutical industry, the unexpected appearance of crystalline forms could impact
the therapeutic efficacy of an Active Pharmaceutical Ingredient (API). For quality control, a …

Solid‐State NMR‐Driven Crystal Structure Prediction of Molecular Crystals: The Case of Mebendazole

F Bravetti, S Bordignon, E Alig… - … A European Journal, 2022 - Wiley Online Library
Among all possible NMR crystallography approaches for crystal‐structure determination,
crystal structure prediction–NMR crystallography (CSP‐NMRX) has recently turned out to be …

Prediction of toluene/water partition coefficients in the SAMPL9 blind challenge: assessment of machine learning and IEF-PCM/MST continuum solvation models

WJ Zamora, A Viayna, S Pinheiro… - Physical Chemistry …, 2023 - pubs.rsc.org
In recent years the use of partition systems other than the widely used biphasic n-
octanol/water has received increased attention to gain insight into the molecular features …

Natural abundance 14 N and 15 N solid-state NMR of pharmaceuticals and their polymorphs

SL Veinberg, KE Johnston, MJ Jaroszewicz… - Physical Chemistry …, 2016 - pubs.rsc.org
14N ultra-wideline (UW), 1H {15N} indirectly-detected HETCOR (idHETCOR) and 15N
dynamic nuclear polarization (DNP) solid-state NMR (SSNMR) experiments, in combination …

In Situ Eutectic Formation in a Polymeric Matrix via Hot-Melt Reactive Extrusion and the Use of Partial Least Squares Regression Modeling for Reaction Yield …

GP Andrews, A Culkin, DS Jones, S Li - Molecular Pharmaceutics, 2024 - ACS Publications
There has been a significant volume of work investigating the design and synthesis of new
crystalline multicomponent systems via examining complementary functional groups that …

Revealing intermolecular hydrogen bonding structure and dynamics in a deep eutectic pharmaceutical by magic-angle spinning NMR spectroscopy

SK Mann, TN Pham, LL McQueen… - Molecular …, 2019 - ACS Publications
Liquid forms of pharmaceuticals (ionic liquids and deep eutectic solvents) offer a number of
potential advantages over solid-state drugs; a key question is the role of intermolecular …

Hybridizing cross-polarization with NOE or refocused-INEPT enhances the sensitivity of MAS NMR spectroscopy

R Zhang, KH Mroue, A Ramamoorthy - Journal of magnetic resonance, 2016 - Elsevier
Heteronuclear cross polarization (CP) has been commonly used to enhance the sensitivity
of dilute low-γ nuclei in almost all solid-state NMR experiments. However, CP relies on …

Crystal engineered albendazole with improved dissolution and material attributes

A Thakur, R Thipparaboina, D Kumar, KS Gouthami… - …, 2016 - pubs.rsc.org
Albendazole (ABZ) is a broad spectrum anthelminthic drug and is in the WHO list of
essential medicines. It is a “brick dust” drug with very poor water solubility (0.2 pg ml− 1 at …

Simultaneous formation of inclusion complex and microparticles containing Albendazole and β-Cyclodextrin by supercritical antisolvent co-precipitation

MD Rosas, CM Piqueras, GK Piva… - Journal of CO2 …, 2021 - Elsevier
Albendazole (ABZ) is an effective anthelmintic and an anticancer candidate. Due to the low
oral bioavailability associated with its poor aqueous solubility, high doses are required, and …