An aversive abstinence syndrome manifests 4–24 h following cessation of chronic use of
nicotine-containing products. Symptoms peak on approximately the 3rd day and taper off …

Nicotine withdrawal is associated with deficits in neurocognitive function including sustained
attention, working memory, and response inhibition. Several convergent lines of evidence …

Objective: To assess whether being able to quit smoking is an early marker of Parkinson
disease (PD) onset rather than tobacco being “neuroprotective,” we analyzed information …

Importance Genome-wide hypothesis-free discovery methods have identified loci that are
associated with heavy smoking in adulthood. Research is needed to understand …

Context Smoking remains a major public health problem. Twin studies indicate that the
ability to quit smoking is substantially heritable, with genetics that overlap modestly with the …

Attention‐deficit/hyperactivity disorder (ADHD) and tobacco smoking are among the most
common and costly psychiatric and behavioral problems. The rates of co‐occurrence of …

Background Addictive disorders are a class of chronic, relapsing mental disorders that are
responsible for increased risk of mental and medical disorders and represent the largest …

Despite effective therapies for smoking cessation, most smokers find quitting difficult and
most successful quitters relapse. Considerable evidence supports a genetic risk for nicotine …

Background Classical genetic studies indicate that nicotine dependence is a substantially
heritable complex disorder. Genetic vulnerabilities to nicotine dependence largely overlap …

The dopamine transporter (DAT) is one of the most relevant and investigated
neurotransmitter transporters. DAT is a plasma membrane protein which plays a …