Molecular mechanisms of neuronal death in brain injury after subarachnoid hemorrhage

J Chen, M Li, Z Liu, Y Wang, K Xiong - Frontiers in Cellular …, 2022 - frontiersin.org
Subarachnoid haemorrhage (SAH) is a common cerebrovascular disease with high
disability and mortality rates worldwide. The pathophysiological mechanisms involved in an …

Insulin resistance in ischemic stroke: Mechanisms and therapeutic approaches

PF Ding, HS Zhang, J Wang, YY Gao, JN Mao… - Frontiers in …, 2022 - frontiersin.org
The pathological condition of insulin resistance prevents the neuroprotective effects of
insulin. Numerous studies have demonstrated that insulin resistance, as an independent risk …

Sirtuins as potential targets for neuroprotection: mechanisms of early brain injury induced by subarachnoid hemorrhage

K Lei, R Wu, J Wang, X Lei, E Zhou, R Fan… - Translational Stroke …, 2024 - Springer
Subarachnoid hemorrhage (SAH) is a prevalent cerebrovascular disease with significant
global mortality and morbidity rates. Despite advancements in pharmacological and surgical …

Selective Activation of G Protein–Coupled Estrogen Receptor 1 (GPER1) Reduces ER Stress and Pyroptosis via AMPK Signaling Pathway in Experimental …

Y Liang, W Fu, Y Tang, H Ye, Y Wang, C Sun… - Molecular …, 2025 - Springer
Neuroinflammation is a critical pathogenic event following hemorrhagic stroke. Endoplasmic
reticulum (ER) stress–induced apoptosis and nucleotide-binding domain, leucine-rich …

[HTML][HTML] Hydrogen inhalation therapy regulates lactic acid metabolism following subarachnoid hemorrhage through the HIF-1α pathway

Z Peng, XJ Li, C Pang, JT Zhang, Q Zhu, JQ Sun… - Biochemical and …, 2023 - Elsevier
The neuroprotective effects of hydrogen have been demonstrated, but the mechanism is still
poorly understood. In a clinical trial of inhaled hydrogen in patients with subarachnoid …

miR-93-5p impairs autophagy-lysosomal pathway via TET3 after subarachnoid hemorrhage

PF Ding, XZ Liu, Z Peng, Y Cui, Y Liu, JT Zhang… - Experimental …, 2024 - Elsevier
Intact autophagy-lysosomal pathway (ALP) in neuronal survival is crucial. However, it
remains unclear whether ALP is intact after subarachnoid hemorrhage (SAH). Ten-eleven …

A superior tool for predicting sepsis in SAH patients: The nomogram outperforms SOFA score

L Yu, S Zou, Q Zhou, B Cheng, J Jin - PloS one, 2025 - journals.plos.org
Objective This study aimed to develop and validate a nomogram to predict the risk of sepsis
in non-traumatic subarachnoid hemorrhage (SAH) patients using data from the MIMIC-IV …

Association between insulin resistance markers and poor prognosis in patients with acute ischemic stroke after intravenous thrombolysis

H Liu, D Liu, P Zuo - The Neurologist, 2024 - journals.lww.com
Objectives: This study aims to investigate the significance of insulin resistance markers in
predicting poor prognosis in acute ischemic stroke (AIS) patients after intravenous …

Triglyceride Glucose Index and Prognosis of Patients with Subarachnoid Hemorrhage

Z Xie, J Wang, S Zhu, M Zhang, X Lv - World Neurosurgery, 2024 - Elsevier
Objective The triglyceride glucose (TyG) index is regarded as a reliable alternative indicator
for measuring insulin resistance. We investigated the association between the prognosis of …

In-Hospital Risk Factors and Short-Term Outcomes for Subarachnoid Hemorrhage

Y Liu, C Wei - International Journal of General Medicine, 2024 - Taylor & Francis
Objective To explore the relevant factors affecting the prognosis of subarachnoid
hemorrhage. Methods 284 patients with subarachnoid hemorrhage who were hospitalized …