Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

RNAi therapeutics have been growing. Patisiran and givosiran, two siRNA-based drugs,
were approved by the Food and Drug Administration in 2018 and 2019, respectively …

Acute myeloid leukemia (AML) is driven by leukemia stem cells (LSCs) that resist
conventional chemotherapy and are the major cause of relapse,. Hypomethylating agents …

Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …

Cancer initiation and proliferation is regulated by both epigenetic and genetic events with
epigenetic modifications being increasingly identified as important targets for cancer …

MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and
stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such …

Circular RNAs (circRNAs) represent a class of non-coding RNAs that are widely expressed
in mammals. However, it is largely unknown about the function of human circRNAs and the …

Historically, systemic self-inflammatory conditions were classified as either autoinflammatory
and caused by the innate immune system or autoimmune and driven by adaptive immune …

The past decade has highlighted the central role of epigenetic processes in cancer
causation, progression and treatment. Next-generation sequencing is providing a window …

Epigenetics is one of the most rapidly expanding fields in biology. The recent
characterization of a human DNA methylome at single nucleotide resolution, the discovery of …