Mitochondria calcium is a double-edged sword. While low levels of calcium are essential to
maintain optimal rates of ATP production, extreme levels of calcium overcoming the …

The eukaryote's mitochondrial network is perhaps the cell's most sophisticated and dynamic
responsive sensing system. Integrating metabolic, oxygen, or danger signals with inputs …

Pulmonary arterial hypertension (PAH) is caused by excessive proliferation of vascular cells,
which occlude the lumen of pulmonary arteries (PAs) and lead to right ventricular failure …

Mitochondria produce around 92% of the ATP used in the typical animal cell by oxidative
phosphorylation using energy from their electrochemical proton gradient. Intramitochondrial …

Background—Evidence suggestive of endoplasmic reticulum (ER) stress in the pulmonary
arteries of patients with pulmonary arterial hypertension has been described for decades but …

Mitochondria are ancient endosymbiotic guests that joined the cells in the evolution of
complex life. While the unique ability of mitochondria to produce adenosine triphosphate …

Mitochondrial Ca 2+ signals have been proposed to accelerate oxidative metabolism and
ATP production to match Ca 2+-activated energy-consuming processes. Efforts to …

Background Pulmonary hypertension (PH) is an enigmatic vascular syndrome characterized
by increased pulmonary arterial pressure and adverse remodelling of the pulmonary …

The Ca2+ coupling between endoplasmic reticulum (ER) and mitochondria is central to
multiple cell survival and cell death mechanisms. Cytoplasmic [Ca2+]([Ca2+] c) spikes and …

Cytosolic Ca 2+ signals are transferred into mitochondria over a huge concentration range.
In our recent work we described uncoupling proteins 2 and 3 (UCP2/3) to be fundamental for …