Besides their function in limiting blood loss and promoting wound healing, experimental
evidence has highlighted platelets as active players in all steps of tumorigenesis including …

Platelets are small anucleate cellular fragments that are released by megakaryocytes and
safeguard vascular integrity through a process termed 'haemostasis'. However, platelets …

Cryogenic electron tomography (cryoET) allows visualization of cellular structures in situ.
However, anisotropic resolution arising from the intrinsic “missing-wedge” problem has …

Aging and chronic inflammation are independent risk factors for the development of
atherothrombosis and cardiovascular disease. We hypothesized that aging-associated …

Cellular electron cryotomography offers researchers the ability to observe macromolecules
frozen in action in situ, but a primary challenge with this technique is identifying molecular …

Systemic antiplatelet treatment represents a promising option to improve the therapeutic
outcomes and therapeutic efficacy of chemotherapy and immunotherapy due to the critical …

Current understanding of tumor immunosuppressive mechanisms forms the basis for
modern day immunotherapies. Immunoregulatory role of platelets in cancer remains largely …

Platelet dense-granules are small organelles specific to the platelet lineage that contain
small molecules (calcium, adenyl nucleotides, serotonin) and are essential for the activation …

Platelets are equipped with RNA processing machineries, such as pre-mRNA splicing, pre-
miRNA processing, and mRNA translation. Since platelets are devoid of a nucleus, most …

During activation the platelet cytoskeleton is reorganized, inducing adhesion to the
extracellular matrix and cell spreading. These processes are critical for wound healing and …