Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

[HTML][HTML] Hydrogen sulfide: An endogenous regulator of the immune system

N Dilek, A Papapetropoulos, T Toliver-Kinsky… - Pharmacological …, 2020 - Elsevier
Hydrogen sulfide (H 2 S) is now recognized as an endogenous signaling gasotransmitter in
mammals. It is produced by mammalian cells and tissues by various enzymes …

Ischemia-reperfusion injury reduces long term renal graft survival: mechanism and beyond

H Zhao, A Alam, AP Soo, AJT George, D Ma - EBioMedicine, 2018 - thelancet.com
Ischemia-reperfusion injury (IRI) during renal transplantation often initiates non-specific
inflammatory responses that can result in the loss of kidney graft viability. However, the long …

Evolution of hydrogen sulfide therapeutics to treat cardiovascular disease

Z Li, DJ Polhemus, DJ Lefer - Circulation Research, 2018 - Am Heart Assoc
Hydrogen sulfide (H2S)—a potent gaseous signaling molecule—has emerged as a critical
regulator of cardiovascular homeostasis. H2S is produced enzymatically by 3 constitutively …

Role of hydrogen sulfide in ischemia‐reperfusion injury

D Wu, J Wang, H Li, M Xue, A Ji… - Oxidative medicine and …, 2015 - Wiley Online Library
Ischemia‐reperfusion (I/R) injury is one of the major causes of high morbidity, disability, and
mortality in the world. I/R injury remains a complicated and unresolved situation in clinical …

Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects

K Módis, EM Bos, E Calzia, H Van Goor… - British journal of …, 2014 - Wiley Online Library
Emerging work demonstrates the dual regulation of mitochondrial function by hydrogen
sulfide (H2S), including, at lower concentrations, a stimulatory effect as an electron donor …

The role of hydrogen sulfide in renal system

X Cao, JS Bian - Frontiers in pharmacology, 2016 - frontiersin.org
Hydrogen sulfide has gained recognition as the third gaseous signaling molecule after nitric
oxide and carbon monoxide. This review surveys the emerging role of H2S in mammalian …

Hydrogen sulfide protects blood–brain barrier integrity following cerebral ischemia

Y Wang, J Jia, G Ao, L Hu, H Liu, Y Xiao… - Journal of …, 2014 - Wiley Online Library
By using two structurally unrelated hydrogen sulfide (H2S) donors 5‐(4‐methoxyphenyl)‐3H‐
1, 2‐dithiole‐3‐thione (ADT) and sodium hydrosulfide (NaHS), this study investigated if H2S …

[HTML][HTML] The future of marginal kidney repair in the context of normothermic machine perfusion

JR DiRito, SA Hosgood, GT Tietjen… - American Journal of …, 2018 - Elsevier
Normothermic machine perfusion (NMP) is a technique that utilizes extracorporeal
membrane oxygenation to recondition and repair kidneys at near body temperature prior to …

Hypothermic machine perfusion of kidneys retrieved from standard and high‐risk donors

I Jochmans, JM O'Callaghan, J Pirenne… - Transplant …, 2015 - Wiley Online Library
Hypothermic machine perfusion (HMP) of kidneys is a long‐established alternative to static
cold storage and has been suggested to be a better preservation method. Today, as our …