The liver is considered a preferential tissue for NK cells residency. In humans, almost 50% of
all intrahepatic lymphocytes are NK cells that are strongly imprinted in a liver-specific …

The liver is an important immunological site that can promote immune tolerance or
activation. Natural killer (NK) cells are a major immune subset within the liver, and therefore …

Hepatitis B virus (HBV) infection is one of the main causes of chronic liver diseases that may
progress to liver cirrhosis and hepatocellular carcinoma. Host immune responses are …

Objective Vaccination against hepatitis B virus (HBV) confers protection from subsequent
infection through immunological memory that is traditionally considered the domain of the …

Five hepatitis viruses (hepatitis A to E) are the leading causes of liver disease worldwide.
Among them, hepatitis B virus (HBV) is responsible for approximately 350 million chronic …

Antiviral effectors such as natural killer (NK) cells have impaired functions in chronic
hepatitis B (CHB) patients. The molecular mechanism responsible for this dysfunction …

Hepatitis B virus (HBV) infection is a leading cause of liver damage and hepatic
inflammation. Upon infection, effective antiviral responses by CD8+ T cells, CD4+ T cells …

Natural killer (NK) cells can induce liver fibrosis remission by killing hepatic stellate cells
(HSCs) and producing interferon (IFN)-γ in a mouse model; however, their anti-fibrotic …

Immune modulatory therapies are widely believed to represent potential therapeutic
strategies for chronic hepatitis B infection (CHB). Among the cellular targets for immune …

Liver fibrosis is the common pathological change of chronic liver diseases characterized by
increased deposition of extracellular matrix and reduced matrix degradation. In response to …