DNA methylation is the most well studied of the epigenetic regulators in relation to
environmental exposures. To date, numerous studies have detailed the manner by which …

Abstract According to the “Developmental Origins of Health and Disease”(DOHaD) concept,
the early-life environment is a critical period for fetal programming. Given the …

Epigenetics is the branch of genetics that studies the different mechanisms that influence
gene expression without direct modification of the DNA sequence. An ever-increasing …

Continuous globalization and industrialization have ensured metals are an increasing
aspect of daily life. Their usefulness in manufacturing has made them vital to national …

Aim: Sex-based differences in response to adverse prenatal environments and infant
outcomes have been observed, yet the underlying mechanisms for this are unclear. The …

Exposure to environmental contaminants during pregnancy has been linked to adverse
outcomes at birth and later in life. The link between prenatal exposures and latent health …

It is thought that germ cells and preimplantation embryos during development are most
susceptible to endogenous and exogenous environmental factors because the epigenome …

Abstract Purpose of Review To summarize recent literature relating early-life environmental
exposures on DNA methylation in the placenta, to identify how variation in placental …

Background: Cadmium (Cd) is a ubiquitous environmental toxicant that can accumulate in
the placenta during pregnancy, where it may impair placental function and affect fetal …

The interaction between the (epi) genetic makeup of an individual and his/her environmental
exposure record (exposome) is accepted as a determinant factor for a significant proportion …