Hybrid small-molecule/protein fluorescent probes are powerful tools for visualizing protein
localization and function in living cells. These hybrid probes are constructed by diverse site …

Fluorescent chemosensors for ions and neutral analytes have been widely applied in many
diverse fields such as biology, physiology, pharmacology, and environmental sciences. The …

Precisely targeted transportation of a long-term tracing regent to a nucleus with low toxicity is
one of the most challenging concerns in revealing cancer cell behaviors. Here, we report a …

Zinc is an essential and second most abundant transition element in the human body after
the iron (Fe3+). Chemosensors have unique nature for detection of various selective metal …

The spatiotemporal fluorescence imaging of biological processes requires effective tools to
label intracellular biomolecules in living systems. This review presents a brief overview of …

Our ability to observe biochemical events with high spatial and temporal resolution is
essential for understanding the functioning of living systems. Intrinsically fluorescent proteins …

Human cellular retinol binding protein II (hCRBPII) was used as a protein engineering
platform to rationally regulate absorptive and emissive properties of a covalently bound …

Conspectus Epigenetic DNA and histone modifications alter chromatin conformation and
regulate gene expression. A major DNA modification is methylation, which is catalyzed by …

Cellular activity is defined by the precise spatiotemporal regulation of various components,
such as ions, small molecules, or proteins. Studying cell physiology consequently requires …

The ability to monitor proteolytic pathways that remove unwanted and damaged proteins
from cells is essential for understanding the multiple processes used to maintain cellular …