Fibrinogen conversion into insoluble fibrin and the formation of a stable clot is the final step
of the coagulation cascade. Fibrin clot porosity and its susceptibility to plasmin-mediated …

In 2018, the International Council for Standardization in Haematology (ICSH) published a
consensus document providing guidance for laboratories on measuring direct oral …

This guidance document was prepared on behalf of the International Council for
Standardization in Haematology (ICSH) for providing haemostasis-related guidance …

Globally, the incidence of thromboembolic diseases has increased in recent years,
accompanied by an increase in patient mortality. Currently, several targeting delivery …

Background There is increasing recognition that menstruating women prescribed
anticoagulants experience heavy menstrual bleeding. Objectives The aim of this study is to …

Endogenous fibrinolysis is a powerful natural defense mechanism against lasting arterial
thrombotic occlusion. Recent prospective studies have shown that impaired endogenous …

Fibrin constitutes a major protein component of intravascular thrombi in all locations. Fibrin
formation and its functions are essential for physiological hemostasis and the pathologic …

Fibrinolysis is of paramount importance in maintaining or regaining the patency of veins and
pulmonary arteries obstructed by thrombi. Growing experimental and clinical evidence …

Coagulation factor XIII (FXIII) is converted by thrombin into its active form, FXIIIa, which
crosslinks fibrin fibers, rendering clots more stable and resistant to degradation. FXIII affects …

Rivaroxaban, as a novel oral anticoagulant agent, emerged in thrombosis management.
This study aimed to compare the efficacy and safety of once-daily rivaroxaban versus dose …