Vascular endothelial growth factor receptors (VEGFRs) are a family of receptor protein
tyrosine kinases that play an important role in the regulation of tumor-induced angiogenesis …

The selective and efficient C–H methylation of sp2 and sp3 carbon centres has become a
powerful transformation in the synthetic toolbox. Due to the potential for profound changes to …

Microtubules play a crucial role in multiple cellular functions including mitosis, cell signaling,
and organelle trafficking, which makes the microtubule an important target for cancer …

Epidermal growth factor receptor (EGFR) is of great significance in mediating cell signaling
transduction and tumor behaviors. Currently, third-generation inhibitors of EGFR, especially …

Deep eutectic solvents (DESs) are among novel and more eco-friendly alternatives to ionic
liquids (ILs) prepared by combining the components and the hydrogen bonds developed …

Overexpression of the epidermal growth factor receptor (EGFR) has been linked to several
human cancers, including esophageal cancer, pancreatic cancer, anal cancer, breast …

The clinical evidence for the success of tyrosine kinase inhibitors in combination with
microtubule-targeting agents prompted us to design and develop single agents that possess …

The design, synthesis, and biological evaluation of a series novel N1‑methyl pyrazolo [4, 3-
d] pyrimidines as inhibitors of tubulin polymerization and colchicine binding were described …

In this research layered double hydroxides functionalized with (3r, 5r, 7r)-1-(3-(triethoxysilyl)
propyl)-1, 3, 5, 7-tetraazaadamantan-1-ium chloride (LDHs–TPTAACl) as a novel, green …

Background Breast cancer is the most common malignancy among women worldwide.
Despite advances in treating breast cancer over the past decades, drug resistance and …