Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …

The eukaryotic initiation factor 4G2 (eIF4G2, DAP5, Nat1, p97) was discovered in 1997. Over
the past two decades, dozens of papers have presented contradictory data on eIF4G2 …

Abnormal resumption of meiosis and decreased oocyte quality are hallmarks of maternal
aging. Transcriptional silencing makes translational control an urgent task during meiosis …

Ribosome profiling, which is based on deep sequencing of ribosome footprints, has served
as a powerful tool for elucidating the regulatory mechanism of protein synthesis. However …

In response to stress stimuli, eukaryotic cells typically suppress protein synthesis. This leads
to the release of mRNAs from polysomes, their condensation with RNA-binding proteins …

Converting genetic information into functional proteins is a complex, multi-step process, with
each step being tightly regulated to ensure the accuracy of translation, which is critical to …

Background TNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF
superfamily that can either induce cell death or activate survival pathways after binding to …

Cellular ageing is one of the main drivers of organismal ageing and holds keys towards
improving the longevity and quality of the extended life. Elucidating mechanisms underlying …

Cellular plasticity is crucial for adapting to ever-changing stimuli. As a result, cells
consistently reshape their translatome, and, consequently, their proteome. The control of …