The integral membrane protein CD44 is constitutively expressed in most tissues, and is the
primary cell surface receptor for hyaluronan (HA). HA is the key scaffolding organizer of …

Receptor-mediated cell mechanosensing plays critical roles in cell spreading, migration,
growth, and survival. Dynamic force spectroscopy (DFS) techniques have recently been …

Reciprocal interactions between the cell nucleus and the extracellular matrix lead to
macroscale tissue phenotype changes. However, little is known about how the extracellular …

In this study, we examine the topography and adhesion images of the cell surface of
neutrophils during the activation process. Our analysis of cell surface parameters indicates …

The increasing incidence of neurodegenerative diseases such as Alzheimer's or Parkinson's
disease represents a significant burden for patients and national health systems. The …

Osteoarthritis (OA), a disease that greatly impacts quality of life, has increasing worldwide
prevalence as the population ages. However, its pathogenic mechanisms have not been …

Mechanical forces are tightly coupled to key cellular processes during organogenesis and
tissue degeneration. Many biological responses to mechanical stimulation are controlled by …

Articular cartilage is a dense extracellular matrix-rich tissue that degrades following chronic
mechanical stress, resulting in osteoarthritis. In this work, hepatoma-derived growth factor …

The study of physics in living systems has driven a revolution in how we understand their
structure, function and behaviors. However, such studies require significant care on the part …

The currently reported study employed the curiously named (but simple) quantitative,
nondestructive technique of Multiple Attenuated Internal Reflection InfraRed (MAIR-IR) …