[HTML][HTML] P-body-like condensates in the germline

M Cassani, G Seydoux - Seminars in cell & developmental biology, 2024 - Elsevier
P-bodies are cytoplasmic condensates that accumulate low-translation mRNAs for
temporary storage before translation or degradation. P-bodies have been best characterized …

Primordial germ cell specification in vertebrate embryos: phylogenetic distribution and conserved molecular features of preformation and induction

CL Hansen, F Pelegri - Frontiers in cell and developmental biology, 2021 - frontiersin.org
The differentiation of primordial germ cells (PGCs) occurs during early embryonic
development and is critical for the survival and fitness of sexually reproducing species. Here …

Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary

Y Liu, ME Kossack, ME McFaul, LN Christensen… - Elife, 2022 - elifesciences.org
Zebrafish are an established research organism that has made many contributions to our
understanding of vertebrate tissue and organ development, yet there are still significant …

A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus

AJ Hardcastle, P Liskova, Y Bykhovskaya… - Communications …, 2021 - nature.com
Keratoconus is characterised by reduced rigidity of the cornea with distortion and focal
thinning that causes blurred vision, however, the pathogenetic mechanisms are unknown. It …

[HTML][HTML] Zebrafish as a model for studying ovarian development: Recent advances from targeted gene knockout studies

J Li, W Ge - Molecular and cellular endocrinology, 2020 - Elsevier
Ovarian development is a complex process controlled by precise coordination of multiple
factors. The targeted gene knockout technique is a powerful tool to study the functions of …

A novel bioengineered miR-127 prodrug suppresses the growth and metastatic potential of triple-negative breast cancer cells

M Umeh-Garcia, C Simion, PY Ho, N Batra, AL Berg… - Cancer research, 2020 - AACR
Abstract miR-127 is downregulated in breast cancer, where it has been shown to suppress
the proliferation, migration, and invasion of breast cancer cells. In triple-negative breast …

The price of human evolution: Cancer-testis antigens, the decline in male fertility and the increase in cancer

J Erenpreisa, NM Vainshelbaum, M Lazovska… - International Journal of …, 2023 - mdpi.com
The increasing frequency of general and particularly male cancer coupled with the reduction
in male fertility seen worldwide motivated us to seek a potential evolutionary link between …

Nanos2 marks precursors of somatic lineages and is required for germline formation in the sea anemone Nematostella vectensis

A Denner, J Steger, A Ries, E Morozova-Link… - Science …, 2024 - science.org
In animals, stem cell populations of varying potency facilitate regeneration and tissue
homeostasis. Notably, germline stem cells in both vertebrates and invertebrates express …

The dynamic regulation of mRNA translation and ribosome biogenesis during germ cell development and reproductive aging

M Mercer, S Jang, C Ni, M Buszczak - Frontiers in Cell and …, 2021 - frontiersin.org
The regulation of mRNA translation, both globally and at the level of individual transcripts,
plays a central role in the development and function of germ cells across species. Genetic …

Analysis of ovarian transcriptomes reveals thousands of novel genes in the insect vector Rhodnius prolixus

VL Coelho, TF de Brito, IA de Abreu Brito… - Scientific reports, 2021 - nature.com
Rhodnius prolixus is a Triatominae insect species and a primary vector of Chagas disease.
The genome of R. prolixus has been recently sequenced and partially assembled, but few …