Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

Sarcomeric protein isoforms are mainly governed by alternative promoter-driven expression,
distinct gene expression, gene mutation and alternative mRNA splicing. The transitions of …

The myocardium responds to chronic pressure or volume overload by activation and
proliferation of cardiac fibroblasts and their differentiation into myofibroblasts. Because α …

Aims Cardiac energetic impairment is a major finding in takotsubo patients. We investigate
specific metabolic adaptations to direct future therapies. Methods and results An …

Rationale: Human pluripotent stem cell (hPSC)–derived cardiomyocytes exhibit the
properties of fetal cardiomyocytes, which limits their applications. Various methods have …

A decline in the function of the microvasculature occurs with ageing. An impairment of
endothelial properties represents a main aspect of age-related microvascular alterations …

Atrial septal defect (ASD) is one of the most frequent congenital heart defects (CHDs) with a
variable phenotypic effect depending on the size of the septal shunt. We identified two …

Modulation of actin isoform expression is a well‐established feature of developmental
phenomena. As one might expect, it is also characteristic of several pathological situations …

Hypertrophic cardiomyopathy (HCM) is a primary disorder of contractility in heart muscle. To
gain mechanistic insight and guide pharmacological rescue, this study models HCM using …

Aims Diabetic cardiomyopathy is characterized by the production of a disorganized fibrotic
matrix in the absence of coronary atherosclerosis and hypertension. We examined whether …