Phosphate homeostasis− a vital metabolic equilibrium maintained through the INPHORS signaling pathway

S Austin, A Mayer - Frontiers in Microbiology, 2020 - frontiersin.org
Cells face major changes in demand for and supply of inorganic phosphate (Pi). Pi is often a
limiting nutrient in the environment, particularly for plants and microorganisms. At the same …

Global analysis of protein arginine methylation

F Zhang, J Kerbl-Knapp, MJR Colman, A Meinitzer… - Cell reports …, 2021 - cell.com
Quantitative information about the levels and dynamics of post-translational modifications
(PTMs) is critical for an understanding of cellular functions. Protein arginine methylation …

Type I arginine methyltransferases are intervention points to unveil the oncogenic Epstein-Barr virus to the immune system

G Angrand, A Quillévéré, N Loaëc, VT Dinh… - Nucleic Acids …, 2022 - academic.oup.com
Abstract The oncogenic Epstein-Barr virus (EBV) evades the immune system but has an
Achilles heel: its genome maintenance protein EBNA1. Indeed, EBNA1 is essential for viral …

Crosstalk of phosphorylation and arginine methylation in disordered SRGG repeats of Saccharomyces cerevisiae fibrillarin and its association with nucleolar …

DL Smith, MA Erce, YW Lai, F Tomasetig… - Journal of molecular …, 2020 - Elsevier
Crosstalk exists when two or more post-translational modifications, nearby in sequence or
3D space, affect each other or a protein's interactions. Saccharomyces cerevisiae protein …

Eukaryote-Conserved Methylarginine Is Absent in Diplomonads and Functionally Compensated in Giardia

SJ Emery-Corbin, JJ Hamey, BRE Ansell… - Molecular biology …, 2020 - academic.oup.com
Methylation is a common posttranslational modification of arginine and lysine in eukaryotic
proteins. Methylproteomes are best characterized for higher eukaryotes, where they are …

Metabolic consequences of polyphosphate synthesis and imminent phosphate limitation

GD Kim, D Qiu, HJ Jessen, A Mayer - Mbio, 2023 - Am Soc Microbiol
Cells stabilize intracellular inorganic phosphate (Pi) to compromise between large
biosynthetic needs and detrimental bioenergetic effects of Pi. Pi homeostasis in eukaryotes …

The transporter PHO84/NtPT1 is a target of aluminum to affect phosphorus absorption in Saccharomyces cerevisiae and Nicotiana tabacum L.

Z Huang, S Zhang, R Chen, Q Zhu, P Shi, Y Shen - Metallomics, 2023 - academic.oup.com
The molecular mechanism of aluminum toxicity in biological systems is not completely
understood. Saccharomyces cerevisiae is one of the most used model organisms in the …

Site-specific phosphorylation of histone H3K36 methyltransferase Set2p and demethylase Jhd1p is required for stress responses in Saccharomyces cerevisiae

RJ Separovich, MWM Wong, TK Bartolec… - Journal of Molecular …, 2022 - Elsevier
Histone lysine methylation is a key epigenetic modification that regulates eukaryotic
transcription. In Saccharomyces cerevisiae, it is controlled by a reduced but evolutionarily …

Perturbation-driven transcriptional heterogeneity impacts cell fitness

F Posas, M Nadal-Ribelles, C Sole, A Diez-Villanueva… - bioRxiv, 2024 - biorxiv.org
Heterogeneity is inherent to living organisms and it determines cell fate and phenotypic
variability. Indeed, even isogenic cell populations vary in quantifiable phenotypes. Here we …