Site-selective modification strategies in antibody–drug conjugates
SJ Walsh, JD Bargh, FM Dannheim… - Chemical Society …, 2021 - pubs.rsc.org
Antibody–drug conjugates (ADCs) harness the highly specific targeting capabilities of an
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …
Metal-free bioorthogonal click chemistry in cancer theranostics
Bioorthogonal chemistry is a powerful tool to site-specifically activate drugs in living systems.
Bioorthogonal reactions between a pair of biologically reactive groups can rapidly and …
Bioorthogonal reactions between a pair of biologically reactive groups can rapidly and …
Contemporary Approaches for Site‐Selective Dual Functionalization of Proteins
Site‐selective protein functionalization serves as an invaluable tool for investigating protein
structures and functions in complicated cellular environments and accomplishing semi …
structures and functions in complicated cellular environments and accomplishing semi …
Site‐and Stereoselective Glycomodification of Biomolecules through Carbohydrate‐Promoted Pictet–Spengler Reaction
B Liu, X Zou, Y Zhang, Y Yang, H Xu… - Angewandte …, 2024 - Wiley Online Library
Carbohydrates play pivotal roles in an array of essential biological processes and are
consequently involved in many diseases. To meet the needs of glycobiology research …
consequently involved in many diseases. To meet the needs of glycobiology research …
Introduction of Carbonyl Groups into Antibodies
EL Gulyak, VA Alferova, VA Korshun, KA Sapozhnikova - Molecules, 2023 - mdpi.com
Antibodies and their derivatives (scFv, Fabs, etc.) represent a unique class of biomolecules
that combine selectivity with the ability to target drug delivery. Currently, one of the most …
that combine selectivity with the ability to target drug delivery. Currently, one of the most …
Single‐Step N‐Terminal Modification of Proteins via a Bio‐Inspired Copper (II)‐Mediated Aldol Reaction
K Hanaya, K Yamoto, K Taguchi… - … A European Journal, 2022 - Wiley Online Library
The chemical modification of proteins is an effective technique for manipulating the
properties and functions of proteins, and for creating protein‐based materials. The N …
properties and functions of proteins, and for creating protein‐based materials. The N …
Bifunctional reagents for formylglycine conjugation: pitfalls and breakthroughs
N Janson, T Krüger, L Karsten, M Boschanski… - …, 2020 - Wiley Online Library
Formylglycine‐generating enzymes specifically oxidize cysteine within the consensus
sequence CxPxR to Cα‐formylglycine (FGly). This noncanonical electrophilic amino acid …
sequence CxPxR to Cα‐formylglycine (FGly). This noncanonical electrophilic amino acid …
Characterization of an N-Allylglyoxylamide-Based Bioorthogonal Nitrone Trap
Aldehydes are attractive bioorthogonal coupling partners. The ease of manipulation of
aldehydes and their orthogonality to other classes of bioorthogonal reactions have inspired …
aldehydes and their orthogonality to other classes of bioorthogonal reactions have inspired …
Enzymatic bioconjugation: a perspective from the pharmaceutical industry
Enzymes have firmly established themselves as bespoke catalysts for small molecule
transformations in the pharmaceutical industry, from early research and development stages …
transformations in the pharmaceutical industry, from early research and development stages …
Secondary amino alcohols: traceless cleavable linkers for use in affinity capture and release
S Pomplun, CR Shugrue, AM Schmitt… - Angewandte Chemie …, 2020 - Wiley Online Library
Capture and release of peptides is often a critical operation in the pathway to discovering
materials with novel functions. However, the best methods for efficient capture impede facile …
materials with novel functions. However, the best methods for efficient capture impede facile …