Various etiological factors, such as head injury, chemical intoxication, tumors, and gene
mutation, can induce epileptogenesis. In animal models, status epilepticus (SE) triggers …

Epileptogenesis is the process of developing an epileptic condition and/or its progression
once it is established. The molecules that initiate, promote, and propagate remarkable …

Microglial calcium signaling is rare in a baseline state but strongly engaged during early
epilepsy development. The mechanism (s) governing microglial calcium signaling are not …

Both Fyn and tau have been associated with neuronal hyperexcitability and neurotoxicity in
many tauopathies, including Alzheimer's disease (AD). Individual genetic ablation of fyn or …

Status epilepticus (SE) induces neuroinflammation and epileptogenesis, but the
mechanisms are not yet fully delineated. The Fyn, a non-receptor Src family tyrosine kinase …

Chemical nerve agents (CNA) are increasingly becoming a threat to both civilians and
military personnel. CNA-induced acute effects on the nervous system have been known for …

We have recently demonstrated the role of the Fyn-PKCδ signaling pathway in status
epilepticus (SE)-induced neuroinflammation and epileptogenesis in experimental models of …

Cranial radiotherapy in children has detrimental effects on cognition, mood, and social
competence in young cancer survivors. Treatments harnessing hippocampal neurogenesis …

Organophosphate (OP) nerve agents are a threat to both the military and civilians. OP
exposure causes cholinergic crisis and status epilepticus (SE) because of irreversible …

Status epilepticus (SE) initiates epileptogenesis to transform normal brain to epileptic state
which is characterized by spontaneous recurrent seizures (SRS). Prior to SRS, progressive …