Aggrescan4D: A comprehensive tool for pH‐dependent analysis and engineering of protein aggregation propensity
Abstract Aggrescan4D (A4D) is an advanced computational tool designed for predicting
protein aggregation, leveraging structural information and the influence of pH. Building upon …
protein aggregation, leveraging structural information and the influence of pH. Building upon …
A review of fifteen years developing computational tools to study protein aggregation
C Pintado-Grima, O Bárcenas, A Bartolomé-Nafría… - Biophysica, 2023 - mdpi.com
The presence of insoluble protein deposits in tissues and organs is a hallmark of many
human pathologies. In addition, the formation of protein aggregates is considered one of the …
human pathologies. In addition, the formation of protein aggregates is considered one of the …
Quantitative comparison of nuclear transport inhibition by SARS coronavirus ORF6 reveals the importance of oligomerization
TY Yoo, TJ Mitchison - … of the National Academy of Sciences, 2024 - National Acad Sciences
Open Reading Frame 6 (ORF6) proteins, which are unique to severe acute respiratory
syndrome-related (SARS) coronavirus, inhibit the classical nuclear import pathway to …
syndrome-related (SARS) coronavirus, inhibit the classical nuclear import pathway to …
A3D database: structure-based predictions of protein aggregation for the human proteome
AE Badaczewska-Dawid, J Garcia-Pardo… - …, 2022 - academic.oup.com
Protein aggregation is associated with many human disorders and constitutes a major
bottleneck for producing therapeutic proteins. Our knowledge of the human protein …
bottleneck for producing therapeutic proteins. Our knowledge of the human protein …
Generation of a soluble African horse sickness virus VP7 protein capable of forming core-like particles
S Bekker, H Huismans, V Van Staden - Viruses, 2022 - mdpi.com
A unique characteristic of the African horse sickness virus (AHSV) major core protein VP7 is
that it is highly insoluble, and spontaneously forms crystalline particles in AHSV-infected …
that it is highly insoluble, and spontaneously forms crystalline particles in AHSV-infected …
Quantification of nuclear transport inhibition by SARS-CoV-2 ORF6 using a broadly applicable live-cell dose-response pipeline
TY Yoo, T Mitchison - bioRxiv, 2021 - biorxiv.org
SARS coronavirus ORF6 inhibits the classical nuclear import pathway to antagonize host
antiviral responses. Several models were proposed to explain its inhibitory function, but …
antiviral responses. Several models were proposed to explain its inhibitory function, but …
Investigating the Role of African Horse Sickness Virus VP7 Protein Crystalline Particles on Virus Replication and Release
S Bekker, CA Potgieter, V Van Staden, J Theron - Viruses, 2022 - mdpi.com
African horse sickness is a deadly and highly infectious disease of equids, caused by
African horse sickness virus (AHSV). AHSV is one of the most economically important …
African horse sickness virus (AHSV). AHSV is one of the most economically important …
Biophysical characterisation of ORF6 from SARS-CoV-2
AJ Pettitt - 2024 - discovery.ucl.ac.uk
Open reading frame 6 (ORF6) from severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) plays an important role in suppressing the immune response in coronavirus disease …
CoV-2) plays an important role in suppressing the immune response in coronavirus disease …
A3D Database: Structure-based Protein Aggregation Predictions for the Human Proteome
AE Badaczewska-Dawid, J Garcia-Pardo, A Kuriata… - bioRxiv, 2021 - biorxiv.org
Motivation Protein aggregation is associated with highly debilitating human disorders and
constitutes a major bottleneck for producing therapeutic proteins. Our knowledge of the …
constitutes a major bottleneck for producing therapeutic proteins. Our knowledge of the …