The immune system enables organisms to combat infections and to eliminate endogenous
challenges. Immune responses can be evoked through diverse inducible pathways …

Type I interferons (IFNs)(IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties,
including induction by viral infection, activation of shared signaling pathways, and …

Innate immunity against pathogens relies on an array of immune receptors to detect
molecular patterns that are characteristic of the pathogens, including receptors that are …

Coronaviruses are animal and human pathogens that can cause lethal zoonotic infections
like SARS and MERS. They have polycistronic plus-stranded RNA genomes and belong to …

Nucleic acids are powerful triggers of innate immunity and can adopt the Z-conformation, an
unusual left-handed double helix. Here, we studied the biological function (s) of Z-RNA …

Microbial infections are recognized by the innate immune system through germline-encoded
pattern recognition receptors (PRRs). As most microbial pathogens contain DNA and/or …

Over the past few years, several groups have identified new genes that are transcriptionally
induced downstream of type I interferon (IFN) signalling and that inhibit infection by …

Many viruses trigger the type I interferon (IFN) system, leading to the transcription of
hundreds of interferon-stimulated genes (ISGs). The products of these ISGs exert numerous …

Autoimmunity and autoinflammation arise from aberrant immunological and inflammatory
responses toward self-components, contributing to various autoimmune diseases and …

The 5′ m7G cap is an evolutionarily conserved modification of eukaryotic mRNA. Decades
of research have established that the m7G cap serves as a unique molecular module that …