Enhancing chemical and physical stability of pharmaceuticals using freeze-thaw method: challenges and opportunities for process optimization through quality by …

SA Bernal-Chávez, A Romero-Montero… - Journal of Biological …, 2023 - Springer
The freeze-thaw (F/T) method is commonly employed during the processing and handling of
drug substances to enhance their chemical and physical stability and obtain pharmaceutical …

Process development and quality attributes for the freeze-drying process in pharmaceuticals, biopharmaceuticals and nanomedicine delivery: a state-of-the-art review

SR Pardeshi, NS Deshmukh, DR Telange… - Future Journal of …, 2023 - Springer
Background Process intensification is a major hurdle in pharmaceutical process scale-up.
Solvent removal strategies have limited the effectiveness of the overall stability of …

Starch nanoparticle preparation by the nanoprecipitation technique: Effects of formulation parameters

KY Hernández-Giottonini, JA Quiñones-Rabago… - Colloids and Surfaces A …, 2024 - Elsevier
This study investigates how key formulation parameters influence the formation of starch
nanoparticles using the nanoprecipitation technique. When loaded with different …

[HTML][HTML] Drug Loading in Chitosan-Based Nanoparticles

Y Herdiana, E Febrina, S Nurhasanah, D Gozali… - Pharmaceutics, 2024 - mdpi.com
Chitosan nanoparticles (CSNPs) are promising vehicles for targeted and controlled drug
release. Recognized for their biodegradability, biocompatibility, low toxicity, and ease of …

Hyaluronic acid nanogels: A promising platform for therapeutic and theranostic applications

SS Myint, C Laomeephol, S Thamnium, S Chamni… - Pharmaceutics, 2023 - mdpi.com
Hyaluronic acid (HA) nanogels are a versatile class of nanomaterials with specific
properties, such as biocompatibility, hygroscopicity, and biodegradability. HA nanogels …

Exploring the Dissolution, Solid-state Properties, and Long-term Storage Stability of Cryoprotectant-free Fenbendazole Nanoparticles

G Bedogni, LV Michelena, K Seremeta, N Okulik… - AAPS …, 2024 - Springer
Fenbendazole is an antiparasitic drug widely used in veterinary medicine to treat parasitic
infections caused in animals like cattle, horses, sheep, and dogs. Recently, it has been …

Flash nanoprecipitation allows easy fabrication of pH-responsive acetalated dextran nanoparticles for intracellular release of payloads

KA Hughes, B Misra, M Maghareh, P Samart, E Nguyen… - Discover Nano, 2024 - Springer
Abstract Acetalated dextran (Ac-Dex) nanoparticles are currently of immense interest due to
their sharp pH-responsive nature and high biodegradability. Ac-Dex nanoparticles are often …

Cryoprotective isoliquiritigenin-zein phosphatidylcholine nanoparticles inhibits breast cancer-bone metastasis by targeting JAK-STAT signaling pathways

K Ganesan, C Xu, C Xie, Y Sui, C Zheng, F Gao… - Chemico-Biological …, 2024 - Elsevier
Breast cancer (BC) is the most common cancer in women and is known for its tendency to
spread to the bones, causing significant health issues and mortality. In this study, we aimed …

[HTML][HTML] Smart hyaluronated micelles to enhance a gemcitabine prodrug efficacy

I Andreana, V Bincoletto, C Ricci, IC Salaroglio… - Journal of Drug Delivery …, 2025 - Elsevier
Self-assembling drug delivery systems have drawn attention over recent decades thanks to
their versatility and easy preparation processes. Of the various nanocarriers available …

Targeting pentamidine towards CD44-overexpressing cells using hyaluronated lipid-polymer hybrid nanoparticles

I Andreana, M Chiapasco, V Bincoletto… - Drug Delivery and …, 2024 - Springer
Biodegradable nanocarriers possess enormous potential for use as drug delivery systems
that can accomplish controlled and targeted drug release, and a wide range of nanosystems …