The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …

Cytokines, many of which signal through the JAK–STAT (Janus kinase–Signal Transducers
and Activators of Transcription) pathway, play a central role in the pathogenesis of …

Janus kinase (JAK) inhibitors (also termed Jakinibs) constitute a family of small drugs that
target various isoforms of JAKs (JAK1, JAK2, JAK3 and/or tyrosine kinase 2 (Tyk2)). They …

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causing the COVID-19
respiratory disease pandemic utilizes unique 2′-o-methyltransferase (2′-O-MTase) …

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused the unprecedented COVID-19 pandemic, which has infected over 178 million people …

ABSTRACT Introduction: Tyrosine kinase 2 (Tyk2) is a non-receptor tyrosine-protein kinase,
an enzyme that in humans is encoded by the TYK2 gene. Tyk2, together with three other …

Background: Current therapeutic options for atopic dermatitis (AD) are limited. Janus kinase
(JAK) inhibitors may be viable alternatives. Objectives: To assess the efficacy and safety of …

Janus kinases (JAKs) are central components in cytokine signaling pathways. A number of
small molecule JAK inhibitors have been approved to treat a wide range of inflammatory and …

JAK1, JAK2, JAK3, and TYK2 belong to the JAK (Janus kinase) family. They play critical
roles in cytokine signaling. Constitutive activation of JAK/STAT pathways is associated with …

Introduction Up to now, a total of eight Janus kinase (JAK) inhibitors have been approved for
the treatment of autoimmune and myeloproliferative disease. The JAK family belongs to the …