Every year, millions of people around the world undergo bone graft and artificial prosthesis
transplants which engenders the repair and/or replacement of native bone for treating bone …

There are more than 2 million bone grafting procedures performed annually in the US alone.
Despite significant efforts, the repair of large segmental bone defects is a substantial clinical …

Critically engineered stiffness and strength of a scaffold are crucial for managing
maladapted stress concentration and reducing stress shielding. At the same time, suitable …

Recently, magnesium (Mg) and its alloys are gaining the attention of researchers as these
materials can provide mechanical properties comparable to natural bone. Additive …

Treatment of bone defects caused by trauma or disease is a major burden on human
healthcare systems. Although autologous bone grafts are considered as the gold standard …

The design and fabrication of tissue engineering scaffolds is a highly complex process. In
order to provide a proper architecture for cells to grow, proliferate, and differentiate to form …

Bone tissue engineering involves the combined use of materials with functional properties to
regenerate bone. Nanohydroxyapatite (nHA) can influence the behavior of cells. The …

Abstract Image-Based Simulation (IBSim) is the process by which a digital representation of
a real geometry is generated from image data for the purpose of performing a simulation …

Scaffolds with gradient pore characteristics have received a great deal of attention as they
can better mimic the structure of the native tissues and concurrently meet both biological and …

Substantial tissue loss, such as in large bone defects, represents a clinical challenge for
which regenerative therapies and tissue engineering strategies aim at offering treatment …