Application of xCELLigence RTCA biosensor technology for revealing the profile and window of drug responsiveness in real time
D Kho, C MacDonald, R Johnson, CP Unsworth… - Biosensors, 2015 - mdpi.com
The xCELLigence technology is a real-time cellular biosensor, which measures the net
adhesion of cells to high-density gold electrode arrays printed on custom-designed E-plates …
adhesion of cells to high-density gold electrode arrays printed on custom-designed E-plates …
Use of Single-Frequency Impedance Spectroscopy to Characterize the Growth Dynamics of Biofilm Formation in Pseudomonas aeruginosa
JBJH van Duuren, M Müsken, B Karge, J Tomasch… - Scientific reports, 2017 - nature.com
Impedance spectroscopy has been applied in prokaryotic and eukaryotic cytometry as a
label-free method for the investigation of adherent cells. In this paper, its use for …
label-free method for the investigation of adherent cells. In this paper, its use for …
Molecular fingerprints of polar narcotic chemicals based on heterozygous essential gene knockout library in Saccharomyces cerevisiae
M Guan, W Ji, Y Xu, L Yan, D Chen, S Li, X Zhang - Chemosphere, 2022 - Elsevier
Cytotoxicity of non-polar narcotic chemicals can be predicted by quantitative structure
activity relationship (QSAR) models, but the polar narcotic chemicals' actual cytotoxicity …
activity relationship (QSAR) models, but the polar narcotic chemicals' actual cytotoxicity …
Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage
Cytotoxicity is a commonly used in vitro endpoint for evaluating chemical toxicity. In support
of the US Tox21 screening program, the cytotoxicity of~ 10K chemicals was interrogated at …
of the US Tox21 screening program, the cytotoxicity of~ 10K chemicals was interrogated at …
Liposomal formulation of hypoxia activated prodrug for the treatment of ovarian cancer
In this work, a new sphingomyelin-cholesterol liposomal formulation (CPD100Li) for the
delivery of a hypoxia activated prodrug of vinblastine, mon-N-oxide (CPD100), is developed …
delivery of a hypoxia activated prodrug of vinblastine, mon-N-oxide (CPD100), is developed …
Machine learning algorithms for mode-of-action classification in toxicity assessment
Abstract Background Real Time Cell Analysis (RTCA) technology is used to monitor cellular
changes continuously over the entire exposure period. Combining with different testing …
changes continuously over the entire exposure period. Combining with different testing …
Persistent Cytotoxicity and Endocrine Activity in the First Oil Sands End-Pit Lake
Oil sands process-affected water (OSPW) is a byproduct of bitumen extraction that has
persistent toxicity owing to its complex mixture of organics. A prominent remediation strategy …
persistent toxicity owing to its complex mixture of organics. A prominent remediation strategy …
Modeling and simulation for toxicity assessment
The effect of various toxicants on growth/death and morphology of human cells is
investigated using the xCELLigence Real-Time Cell Analysis High Troughput in vitro assay …
investigated using the xCELLigence Real-Time Cell Analysis High Troughput in vitro assay …
Functional genomics assessment of narcotic and specific acting chemical pollutants using E. coli
The knowledge of gene-chemical interaction can be used to derive toxicological mechanism
of chemical pollutants, therefore, it might be useful to discriminate chemicals with different …
of chemical pollutants, therefore, it might be useful to discriminate chemicals with different …
Functional non-parametric mixed effects models for cytotoxicity assessment and clustering
T Ma, D Richard, YB Yang, AB Kashlak, C Anton - Scientific Reports, 2023 - nature.com
A multitude of natural and synthetic chemicals are present in our environment. Through the
study of a compound's cytotoxicity, researchers can carefully set regulations regarding how …
study of a compound's cytotoxicity, researchers can carefully set regulations regarding how …